AREG

Also known as AR, AREGB, CRDGF, SDGF, amphiregulin

Amphiregulin, also known as AREG, is a protein synthesized as a transmembrane glycoprotein with 252 aminoacids and it is encoded by the AREG gene. in humans.

Gene data

AREG

Name: amphiregulin
Type: protein-coding
Position: 74,444,999–74,455,005 (+)
Aliases: AR, AREGB, CRDGF, SDGF
Ensembl: ENSG00000109321
RefSeq RNA: NM_001657.4
RefSeq protein: NP_001648.1

The protein encoded by this gene is a member of the epidermal growth factor family. It is an autocrine growth factor as well as a mitogen for astrocytes, Schwann cells and fibroblasts. It is related to epidermal growth factor (EGF) and transforming growth factor alpha (TGF-alpha). The protein interacts with the EGF/TGF-alpha receptor to promote the growth of normal epithelial cells, and it inhibits the growth of certain aggressive carcinoma cell lines. It also functions in mammary gland, oocyte and bone tissue development. This gene is associated with a psoriasis-like skin phenotype, and is also associated with other pathological disorders, including various types of cancers and inflammatory conditions. [provided by RefSeq, Apr 2014].

Gene Ontology

Biological process

epidermal growth factor receptor signaling pathway epidermal growth factor receptor signaling pathway epidermal growth factor receptor signaling pathway G protein-coupled receptor signaling pathway cell-cell signaling positive regulation of cell population proliferation positive regulation of cell population proliferation positive regulation of cell population proliferation

Molecular function

epidermal growth factor receptor binding epidermal growth factor receptor binding protein binding growth factor activity growth factor activity growth factor activity transmembrane receptor protein tyrosine kinase activator activity transmembrane receptor protein tyrosine kinase activator activity

Cellular component

extracellular region extracellular region extracellular region extracellular region extracellular region extracellular region nucleus cytoplasm

Pathways

MAPK signaling pathway - Homo sapiens (human)ErbB signaling pathway - Homo sapiens (human)PI3K-Akt signaling pathway - Homo sapiens (human)Hippo signaling pathway - Homo sapiens (human)Colorectal cancer - Homo sapiens (human)PIP3 activates AKT signaling Developmental Biology Signal Transduction Disease Signaling by EGFR in Cancer

via MyGene.info

Wikidata facts

Show 5 more facts

exact match: identifiers.org/ncbigene/374
HomoloGene ID: 1252
genomic start: 74445136
genomic end: 74455005
cytogenetic location: 4q13.3

Sources (6)

via Wikidata · CC0

~7 min read

Article

12 sections

Contents

Function
Biological role
Clinical significance
Role in tissue repair
Psoriasis
Cancer
Rheumatoid arthritis
Fibrosis
Inflammation
References
Further reading
External links

Amphiregulin, also known as AREG, is a protein synthesized as a transmembrane glycoprotein with 252 aminoacids and it is encoded by the AREG gene. in humans.

== Function == The protein encoded by this gene is a member of the epidermal growth factor (EGF) family.