FKBP2
Sign in to saveAlso known as FKBP-13, PPIase, FK506 binding protein 2, FKBP prolyl isomerase 2, FKBP13
FK506-binding protein 2 is a protein that in humans is encoded by the FKBP2 gene.
Gene data
FKBP2- Name
- FKBP prolyl isomerase 2
- Type
- protein-coding
- Position
- 64,241,003–64,244,583 (+)
- Aliases
- FKBP-13, FKBP13, PPIase
- Ensembl
- ENSG00000173486
- RefSeq RNA
- NM_001135208.2, NM_001370360.1, NM_001370362.1, NM_001370363.1, NM_001370365.1
- RefSeq protein
- NP_001128680.1, NP_001357289.1, NP_001357291.1, NP_001357292.1, NP_001357294.1
The protein encoded by this gene is a member of the immunophilin protein family, which play a role in immunoregulation and basic cellular processes involving protein folding and trafficking. This encoded protein is a cis-trans prolyl isomerase that binds the immunosuppressants FK506 and rapamycin. It is thought to function as an ER chaperone and may also act as a component of membrane cytoskeletal scaffolds. Multiple alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Sep 2008].
Gene Ontology
Molecular function
Cellular component
Pathways
via MyGene.info
Gene · Ensembl
FKBP prolyl isomerase 2
- Symbol
- FKBP2
- Biotype
- Protein coding
- Organism
- Homo sapiens
- Location
- 11:64,241,003-64,244,583
- Strand
- Forward (+)
- Assembly
- GRCh38
via Ensembl · EMBL-EBI
Wikidata facts
- Instance of
- gene
- Image
- Protein FKBP2 PDB 2pbc.png
Show 7 more facts
- HomoloGene ID
- 40604
- found in taxon
- Homo sapiens
- exact match
- identifiers.org/ncbigene/2286
- genomic start
- 64008475
- chromosome
- human chromosome 11
- genomic end
- 64244134
- cytogenetic location
- 11q13.1
Sources (4)
via Wikidata · CC0
~1 min read
Encyclopedic overview
4 sectionsContents
- Function
- Interactions
- References
- Further reading
FK506-binding protein 2 is a protein that in humans is encoded by the FKBP2 gene.
== Function ==
Excerpted from Wikipedia’s “FKBP2” article, available under the CC BY-SA 4.0 licence.