Structure via PubChem · Public domain (PubChem)
artemotil
Sign in to saveAlso known as beta-arteether, (1R)-arteether
Artemotil (INN; also known as β-arteether), is a fast acting blood schizonticide specifically indicated for the treatment of chloroquine-resistant Plasmodium falciparum malaria and cerebral malaria cases. It is a semi-synthetic derivative of artemisinin, a natural product of the Chinese plant Artemisia annua. It is currently only used as a second line drug in severe cases of malaria.
Chemical data
- Formula
- C17H28O5
- Molecular weight
- 312.4 g/mol
- IUPAC name
- (1R,4S,5R,8S,9R,10S,12R,13R)-10-ethoxy-1,5,9-trimethyl-11,14,15,16-tetraoxatetracyclo[10.3.1.04,13.08,13]hexadecane
- SMILES
- CCO[C@@H]1[C@@H]([C@@H]2CC[C@H]([C@H]3[C@]24[C@H](O1)O[C@@](CC3)(OO4)C)C)C
- InChIKey
- NLYNIRQVMRLPIQ-XQLAAWPRSA-N
- XLogP
- 3.4
- Polar surface area
- 46.2 Ų
- H-bond donors
- 0
- H-bond acceptors
- 5
- Formal charge
- 0
via PubChem
Drug data · ChEMBL
- Max clinical phase
- Phase 2
- Molecule type
- Small molecule
- Indications
- malaria
via ChEMBL · EBI
Wikidata facts
- Mass
- 312.19367399600003
Show 3 more facts
- canonical SMILES
- CCOC1OC2OC3(C)CCC4C(C)CCC(C1C)C24OO3
- chemical formula
- C₁₇H₂₈O₅
- isomeric SMILES
- CCO[C@@H]1[C@@H]([C@@H]2CC[C@H]([C@H]3[C@]24[C@H](O1)O[C@@](CC3)(OO4)C)C)C
Sources (2)
via Wikidata · CC0
~1 min read
Encyclopedic overview
1 sectionsContents
- References
Artemotil (INN; also known as β-arteether), is a fast acting blood schizonticide specifically indicated for the treatment of chloroquine-resistant Plasmodium falciparum malaria and cerebral malaria cases. It is a semi-synthetic derivative of artemisinin, a natural product of the Chinese plant Artemisia annua. It is currently only used as a second line drug in severe cases of malaria.
==References==
Excerpted from Wikipedia’s “artemotil” article, available under the CC BY-SA 4.0 licence.
Available in 11 languages
via Wikidata sitelinks · CC0