tafenoquine
Sign in to saveTafenoquine, sold under the brand name Krintafel among others, is a medication used to prevent and to treat malaria. With respect to acute malaria, it is used together with other medications to prevent relapse by Plasmodium vivax. It may be used to prevent all types of malaria. It is taken by mouth.
Key facts
- Drug.Verifiedfields
- changed
- Drug.Watchedfields
- changed
- Drug.verifiedrevid
- 470476706
- Drug.image
- Tafenoquine.svg
- Drug.image_class
- skin-invert-image
- Drug.pronounce
- ta fen' oh kwin
- Drug.tradename
- Krintafel, Arakoda, others
- Drug.MedlinePlus
- a618050
- Drug.DailyMedID
- Tafenoquine
- Drug.pregnancy_AU
- C
- Drug.routes_of_administration
- By mouth
- Drug.class
- Antimalarial
- Drug.ATC_prefix
- P01
- Drug.ATC_suffix
- BA07
- Drug.legal_AU
- S4
- Drug.legal_US
- Rx-only
- Drug.index2_label
- as salt
- Drug.CAS_number
- 106635-80-7
via Wikipedia infobox
Chemical data
- Formula
- C24H28F3N3O3
- Molecular weight
- 463.5 g/mol
- IUPAC name
- 4-N-[2,6-dimethoxy-4-methyl-5-[3-(trifluoromethyl)phenoxy]quinolin-8-yl]pentane-1,4-diamine
via PubChem
Research
404 papers- Tafenoquine and G6PD: a primer for clinicians.Journal of travel medicine · 2019
- Tafenoquine: a toxicity overview.Expert opinion on drug safety · 2021
- Tafenoquine.2012
- Tafenoquine: the new kid on the block.Current opinion in infectious diseases · 2019
- Tafenoquine.2006
via PubMed
Wikidata facts
- Subclass of
- chemical compound
- Mass
- +463.208
Show 2 more facts
- P2868
- antimalarial
- P366
- medication
via Wikidata · CC0
Article
10 sectionsContents
- Medical use
- Prevention
- Treatment
- Chemistry
- Synthesis
- History
- Society and culture
- Names
- References
- External links
Tafenoquine, sold under the brand name Krintafel among others, is a medication used to prevent and to treat malaria. With respect to acute malaria, it is used together with other medications to prevent relapse by Plasmodium vivax. It may be used to prevent all types of malaria. It is taken by mouth.
Common side effects include vomiting, headache, and dizziness. Other side effects may include methemoglobinemia, trouble sleeping, and anaphylaxis. In people with G6PD deficiency, red blood cell breakdown may occur. Use in pregnancy is not recommended. Tafenoquine is in the 8-aminoquinoline family of medications. The mechanism of action is unclear but it is effective both in the liver and bloodstream. A possible mechanism of action and other novel perspectives have been published.