Structure via PubChem · Public domain (PubChem)
nitazoxanide
Sign in to saveAlso known as PH-5776, Alinia, Nodik, Adrovet, Omniparax, Nitaxozanid, Nitaxozanide, Nitazoxanida
Nitazoxanide, sold under the brand name Alinia among others, is a broad-spectrum antiparasitic and broad-spectrum antiviral medication that is used in medicine for the treatment of various helminthic, protozoal, and viral infections. It is indicated for the treatment of infection by Cryptosporidium parvum and Giardia lamblia in immunocompetent individuals and has been repurposed for the treatment of influenza. Nitazoxanide has also been shown to have in vitro antiparasitic activity and clinical treatment efficacy for infections caused by other protozoa and helminths; evidence suggested that it
Chemical data
- Formula
- C12H9N3O5S
- Molecular weight
- 307.28 g/mol
- IUPAC name
- [2-[(5-nitro-1,3-thiazol-2-yl)carbamoyl]phenyl] acetate
- SMILES
- CC(=O)OC1=CC=CC=C1C(=O)NC2=NC=C(S2)[N+](=O)[O-]
- InChIKey
- YQNQNVDNTFHQSW-UHFFFAOYSA-N
- XLogP
- 2
- Polar surface area
- 142 Ų
- H-bond donors
- 1
- H-bond acceptors
- 7
- Formal charge
- 0
via PubChem
Research
1,193 papers- Nitazoxanide and COVID-19: A review.Molecular biology reports · 2022
- Nitazoxanide treatment for norovirus infection in solid organ transplant recipients.Clinical transplantation · 2022
- High-throughput screening unveils nitazoxanide as a potent PRRSV inhibitor by targeting NMRAL1.Nature communications · 2024
- Nitazoxanide.Indian pediatrics · 2005
- Nitazoxanide: a first-in-class broad-spectrum antiviral agent.Antiviral research · 2014
via PubMed
Wikidata facts
- Subclass of
- chemical compound
- Country
- Brazil
- Mass
- 307.026
- Has use
- medication
Show 7 more facts
- subject has role
- enzyme inhibitor
- chemical formula
- C₁₂H₉N₃O₅S
- medical condition treated
- giardiasis
- canonical SMILES
- CC(=O)OC1=CC=CC=C1C(=O)NC2=NC=C(S2)[N+](=O)[O-]
- defined daily dose
- 1
- Commons category
- Nitazoxanide
- found in taxon
- Streptomyces
via Wikidata · CC0
~10 min read
Encyclopedic overview
18 sectionsContents
- Uses
- Chronic hepatitis B
- Chronic hepatitis C
- Contraindications
- Adverse effects
- Overdose
- Interactions
- Pharmacology
- Pharmacodynamics
- Pharmacokinetics
- Chemistry
- History
- Pharmaceutical products
- Dosage forms
- Brand names
- Research
- References
- Further reading
Nitazoxanide, sold under the brand name Alinia among others, is a broad-spectrum antiparasitic and broad-spectrum antiviral medication that is used in medicine for the treatment of various helminthic, protozoal, and viral infections. It is indicated for the treatment of infection by Cryptosporidium parvum and Giardia lamblia in immunocompetent individuals and has been repurposed for the treatment of influenza. Nitazoxanide has also been shown to have in vitro antiparasitic activity and clinical treatment efficacy for infections caused by other protozoa and helminths; evidence suggested that it possesses efficacy in treating a number of viral infections as well.
Chemically, nitazoxanide is the prototype member of the thiazolides, a class of drugs which are synthetic nitrothiazolyl-salicylamide derivatives with antiparasitic and antiviral activity. Tizoxanide, an active metabolite of nitazoxanide in humans, is also an antiparasitic drug of the thiazolide class.
Excerpted from Wikipedia’s “nitazoxanide” article, available under the CC BY-SA 4.0 licence.