nitisinone

Also known as Orfadin®, SC-0735, 2-(alpha,alpha,alpha-Trifluoro-2-nitro-p-tuluoyl)-1,3-cyclohexanedione

Nitisinone, sold under the brand name Orfadin among others, is a medication used for the treatment of hereditary tyrosinemia type 1; or for the reduction of urine homogentisic acid in adults with alkaptonuria. Nitisinone is a hydroxyphenyl-pyruvate dioxygenase inhibitor.

Key facts

Drug.PubChem: 115355
Drug.image: Nitisinone.svg
Drug.image_class: skin-invert-image
Drug.image2: Nitisinone (ball-and-stick).png
Drug.image_class2: bg-transparent
Drug.tradename: Orfadin, others
Drug.DailyMedID: Nitisinone
Drug.routes_of_administration: By mouth
Drug.ATC_prefix: A16
Drug.ATC_suffix: AX04
Drug.legal_CA: Rx-only
Drug.legal_US: Rx-only
Drug.legal_EU: Rx-only
Drug.elimination_half life: Approximately 54 h (Range: 39 to 86 hours)
Drug.CAS_number: 104206-65-7
Drug.IUPHAR_ligand: 6834
Drug.DrugBank: DB00348
Drug.ChemSpiderID: 103195

via Wikipedia infobox

Research

444 papers

Nitisinone.2006
Suitability of nitisinone for alkaptonuria.The lancet. Diabetes & endocrinology · 2020
Nitisinone.2012
Nitisinone.2026
The Discovery of the Mode of Action of Nitisinone.Metabolites · 2022

via PubMed

Wikidata facts

Mass: 329.051107

Show 5 more facts

chemical formula: C₁₄H₁₀F₃NO₅
canonical SMILES: C1CC(=O)C(C(=O)C1)C(=O)C2=C(C=C(C=C2)C(F)(F)F)[N+](=O)[O-]
World Health Organisation international non-proprietary name: nitisinone
defined daily dose: 20
Commons category: Nitisinone

Sources (4)

via Wikidata · CC0

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