ASB2

Also known as ASB-2, ankyrin repeat and SOCS box containing 2

Ankyrin repeat and SOCS box protein 2 (ASBS) is a protein that is encoded by the ASB2 gene in humans.

Gene data

ASB2

Name: ankyrin repeat and SOCS box containing 2
Type: protein-coding
Aliases: ASB-2

This gene encodes a member of the ankyrin repeat and SOCS box-containing (ASB) protein family. These proteins play a role in protein degradation by coupling suppressor of cytokine signalling (SOCS) proteins with the elongin BC complex. The encoded protein is a subunit of a multimeric E3 ubiquitin ligase complex that mediates the degradation of actin-binding proteins. This gene plays a role in retinoic acid-induced growth inhibition and differentiation of myeloid leukemia cells. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Jan 2011].

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Gene · Ensembl

ankyrin repeat and SOCS box containing 2

Symbol: ASB2
Biotype: Protein coding
Organism: Homo sapiens
Location: 14:93,933,783-93,978,831
Strand: Reverse (−)
Assembly: GRCh38

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via Ensembl · EMBL-EBI

Wikidata facts

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HomoloGene ID: 69202
exact match: identifiers.org/ncbigene/51676
genomic start: 93934166
genomic end: 93976739
cytogenetic location: 14q32.12

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Ankyrin repeat and SOCS box protein 2 (ASBS) is a protein that is encoded by the ASB2 gene in humans.

The ASB2 protein belongs to the ankyrin repeat and SOCS box-containing (ASB) family of proteins. It consists of an ankyrin repeat sequence and a SOCS box domain. The SOCS box plays a role in connecting suppressor of cytokine signaling (SOCS) proteins and their binding partners with the elongin B and C complex, potentially facilitating their degradation. This gene is induced by all-trans retinoic acid. In myeloid leukemia cells, the expression of this encoded protein has been shown to induce growth inhibition and chromatin condensation. Multiple alternatively spliced transcript variants have been described for this gene but their full length sequences are not known.