BCL11A

Name

BCL11 transcription factor A

Type

protein-coding

Position

60,450,520–60,554,467 (−)

Aliases

CTIP1, DILOS, EVI9, HBFQTL5, SMARCM1, ZNF856

Ensembl

ENSG00000119866

RefSeq RNA

NM_001363864.1, NM_001365609.1, NM_001405708.1, NM_001405709.1, NM_001405710.1

RefSeq protein

NP_001350793.1, NP_001352538.1, NP_001392637.1, NP_001392638.1, NP_001392639.1

This gene encodes a C2H2 type zinc-finger protein by its similarity to the mouse Bcl11a/Evi9 protein. The corresponding mouse gene is a common site of retroviral integration in myeloid leukemia, and may function as a leukemia disease gene, in part, through its interaction with BCL6. During hematopoietic cell differentiation, this gene is down-regulated. It is possibly involved in lymphoma pathogenesis since translocations associated with B-cell malignancies also deregulates its expression. Multiple transcript variants encoding several different isoforms have been found for this gene. [provided by RefSeq, Jul 2008].

via MyGene.info

Gene · Ensembl

BCL11 transcription factor A

Symbol

BCL11A

Biotype

Protein coding

Organism

Homo sapiens

Location

2:60,450,520-60,554,467

Strand

Reverse (−)

Assembly

GRCh38

Wikidata facts

Instance of

gene

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