ARID1A

Also known as B120, BAF250, BAF250a, BM029, C1orf4, ELD, MRD14, OSA1

AT-rich interactive domain-containing protein 1A is a protein that in humans is encoded by the ARID1A gene.

In the Vinony graph

Vinony's link graph records 834 inbound references to ARID1A, and connects out to Q180686, Ensembl genome database project and homeobox.

It is catalogued under topics including Genes on human chromosome 1 and Transcription factors.

Vinony links it to 10 Wikipedia language editions.

Gene data

ARID1A

Name: AT-rich interaction domain 1A
Type: protein-coding
Position: 26,693,236–26,782,104 (+)
Aliases: B120, BAF250, BAF250a, BM029, C1orf4, CSS2, ELD, MRD14, OSA1, P270
Ensembl: ENSG00000117713
RefSeq RNA: NM_006015.6, NM_018450.4, NM_139135.4
RefSeq protein: NP_006006.3, NP_624361.1

This gene encodes a member of the SWI/SNF family, whose members have helicase and ATPase activities and are thought to regulate transcription of certain genes by altering the chromatin structure around those genes. The encoded protein is part of the large ATP-dependent chromatin remodeling complex SNF/SWI, which is required for transcriptional activation of genes normally repressed by chromatin. It possesses at least two conserved domains that could be important for its function. First, it has a DNA-binding domain that can specifically bind an AT-rich DNA sequence known to be recognized by a SNF/SWI complex at the beta-globin locus. Second, the C-terminus of the protein can stimulate glucocorticoid receptor-dependent transcriptional activation. It is thought that the protein encoded by this gene confers specificity to the SNF/SWI complex and may recruit the complex to its targets through either protein-DNA or protein-protein interactions. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008].