Beta-secretase 1
Sign in to saveAlso known as BACE1, transmembrane aspartic proteinase Asp2, beta-site APP cleaving enzyme 1, beta-site APP-cleaving enzyme, APP beta-secretase, memapsin-2, beta-secretase 1 precursor variant 1, aspartyl protease 2
mammalian protein found in Homo sapiens
Protein · UniProt
Beta-secretase 1
- Gene
- BACE1
- Organism
- Homo sapiens (Human)
- Length
- 501 aa
- Molecular mass
- 55,764 Da
- Evidence
- 1: Evidence at protein level
Responsible for the proteolytic processing of the amyloid precursor protein (APP). Cleaves at the N-terminus of the A-beta peptide sequence, between residues 671 and 672 of APP, leads to the generation and extracellular release of beta-cleaved soluble APP, and a corresponding cell-associated C-terminal fragment which is later released by gamma-secretase (PubMed:10656250, PubMed:10677483, PubMed:20354142). Cleaves CHL1 (By similarity)
3D-structureAcetylationAlternative splicingAspartyl proteaseCell membraneCell projectionCytoplasmic vesicleDirect protein sequencing
View on UniProt →
Swiss-Prot (reviewed) · via UniProt
Clinical Trials
5 registered- PHASE1TERMINATEDPhase 1 Trial of Na-ASP-2 Hookworm Vaccine in Previously Infected Brazilian AdultsAlbert B. Sabin Vaccine Institute · NCT00473967
- PHASE1WITHDRAWNA Clinical Trial to Study Single- and Multiple- Doses of GSM-779690T in Healthy ParticipantsActa Pharmaceuticals, Inc · NCT07155980
- PHASE1COMPLETEDStudy of Na-ASP-2 Human Hookworm Vaccine in Healthy Adults Without Evidence of Hookworm InfectionBaylor College of Medicine · NCT00120081
- NACOMPLETEDDevelopment of a Skin Test for the Na-ASP-2 Hookworm AntigenAlbert B. Sabin Vaccine Institute · NCT00603889
- NACOMPLETEDPrevalence of Hookworm Infection and Community Preparedness for Hookworm Vaccine Trials in Endemic Areas of BrazilAlbert B. Sabin Vaccine Institute · NCT00939198