exopeptidase
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An exopeptidase is any peptidase that catalyzes the cleavage of the terminal (or the penultimate) peptide bond; the process releases a single amino acid, dipeptide or a tripeptide from the peptide chain. Depending on whether the amino acid is released from the amino or the carboxy terminal (N-terminus or C-terminus), an exopeptidase is further classified as an aminopeptidase or a carboxypeptidase, respectively. Thus, an aminopeptidase, an enzyme in the brush border of the small intestine, will cleave a single amino acid from the amino terminal, whereas carboxypeptidase, which is a digestive en
In the Vinony graph
Within Vinony's link graph, exopeptidase is referenced by 171 other articles, and connects out to peptidase, International Standard Book Number and enzyme.
Vinony files it under EC 3.4 and Enzymes.
Its subject is documented across 17 Wikipedia language editions.
Research
54,748 papers- Engineered nanopores for exopeptidase protein sequencing.Nature methods · 2024
- Exopeptidase Assisted N- and C-Terminal Proteome Sequencing.Analytical chemistry · 2020
- Exopeptidase combination enhances the degradation of isotopically labelled gluten immunogenic peptides in humans.Frontiers in immunology · 2024
- Review Article: Novel Enzyme Therapy Design for Gluten Peptide Digestion Through Exopeptidase Supplementation.Alimentary pharmacology & therapeutics · 2025
- Exopeptidase treatment combined with Maillard reaction modification of protein hydrolysates derived from porcine muscle and plasma: Structure-taste relationship.Food chemistry · 2020
via PubMed
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Encyclopedic overview
3 sectionsContents
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An exopeptidase is any peptidase that catalyzes the cleavage of the terminal (or the penultimate) peptide bond; the process releases a single amino acid, dipeptide or a tripeptide from the peptide chain. Depending on whether the amino acid is released from the amino or the carboxy terminal (N-terminus or C-terminus), an exopeptidase is further classified as an aminopeptidase or a carboxypeptidase, respectively. Thus, an aminopeptidase, an enzyme in the brush border of the small intestine, will cleave a single amino acid from the amino terminal, whereas carboxypeptidase, which is a digestive enzyme present in pancreatic juice, will cleave a single amino acid from the carboxylic end of the peptide.
Some examples of exopeptidases include: Carboxypeptidase A - cleaves C-terminal Phe, Tyr, Trp, or Leu Carboxypeptidase B - cleaves C-terminal Lys or Arg Aminopeptidase - cleaves any N-terminal amino acid Prolinase - cleaves N-terminal Pro from dipeptides Prolidase - cleaves C-terminal Pro from dipeptides
Excerpted from Wikipedia’s “exopeptidase” article, available under the CC BY-SA 4.0 licence.