Structure via PubChem · Public domain (PubChem)
ensaculin
Sign in to saveEnsaculin (KA-672) is a drug from the coumarin family, which has been researched as a potential treatment for dementia. It acts on a number of receptor systems, being both a weak NMDA antagonist and a 5HT1A agonist. Animal studies have shown promising nootropic effects, although efficacy in humans has yet to be proven. It was well tolerated in human trials, with the main side effect being orthostatic hypotension (low blood pressure upon standing).
Chemical data
- Formula
- C26H32N2O5
- Molecular weight
- 452.5 g/mol
- IUPAC name
- 7-methoxy-6-[3-[4-(2-methoxyphenyl)piperazin-1-yl]propoxy]-3,4-dimethylchromen-2-one
- SMILES
- CC1=C(C(=O)OC2=CC(=C(C=C12)OCCCN3CCN(CC3)C4=CC=CC=C4OC)OC)C
- InChIKey
- FQELZLMTAPJJOL-UHFFFAOYSA-N
- XLogP
- 4.1
- Polar surface area
- 60.5 Ų
- H-bond donors
- 0
- H-bond acceptors
- 7
- Formal charge
- 0
via PubChem
Drug data · ChEMBL
- Max clinical phase
- Phase 2
- Molecule type
- Small molecule
via ChEMBL · EBI
Wikidata facts
- Subclass of
- chemical compound
- Mass
- 452.231
Show 3 more facts
- chemical formula
- C₂₆H₃₂N₂O₅
- canonical SMILES
- CC1=C(C(=O)OC2=CC(=C(C=C12)OCCCN3CCN(CC3)C4=CC=CC=C4OC)OC)C
- subject has role
- nootropic
Sources (2)
via Wikidata · CC0
~1 min read
Encyclopedic overview
2 sectionsContents
- See also
- References
Ensaculin (KA-672) is a drug from the coumarin family, which has been researched as a potential treatment for dementia. It acts on a number of receptor systems, being both a weak NMDA antagonist and a 5HT1A agonist. Animal studies have shown promising nootropic effects, although efficacy in humans has yet to be proven. It was well tolerated in human trials, with the main side effect being orthostatic hypotension (low blood pressure upon standing).
==See also== Enciprazine Mafoprazine BMY-14802 Azaperone Fluanisone
Excerpted from Wikipedia’s “ensaculin” article, available under the CC BY-SA 4.0 licence.