bisindolylmaleimide 1

Also known as bisindolylmaleimide I, GF 109203X, Gö6850, Rbt205 Inhibitor, go-6850, BIM-1

BIM-1 (GF 109203X) and the related compounds BIM-2, BIM-3, and BIM-8 are bisindolylmaleimide-based protein kinase C (PKC) inhibitors. These inhibitors also inhibit PDK1 explaining the higher inhibitory potential of LY33331 compared to the other BIM compounds a bisindolylmaleimide inhibitor toward PDK1.

Research

2,067 papers

Inhibition by Wnt-1 or Wnt-3a of nerve growth factor-induced differentiation of PC12 cells is reversed by bisindolylmaleimide-I but not by several other PKC inhibitors.Oncogene · 2002
Bisindolylmaleimide Ligands Stabilize c-MYC G-Quadruplex DNA Structure and Downregulate Gene Expression.Biochemistry · 2022
Protein Kinase C-Independent Inhibition of Organic Cation Transporter 1 Activity by the Bisindolylmaleimide Ro 31-8220.PloS one · 2015
Bisindolylmaleimide IX is a potent inducer of apoptosis in chronic lymphocytic leukaemic cells and activates cleavage of Mcl-1.Leukemia · 2003
Direct block by bisindolylmaleimide of the voltage-dependent K+ currents of rat mesenteric arterial smooth muscle.European journal of pharmacology · 2004

via PubMed

Article

4 sections

Contents

Function
Scope
Interactions
References

{{Chembox | Name = BIM-1 | ImageFile = Bis(indolyl)maleimide.svg | ImageSize = 200px | IUPACName = 3-{1-[3-(Dimethylamino)propyl]-1H-indol-3-yl}-4-(1H-indol-3-yl)-1H-pyrrole-2,5-dione | OtherNames = RBT205 INHIBITOR, BI1 |Section1= |Section2= |Section3= }}