bradykinin

Bradykinin (BK) (from Greek brady- 'slow' + -kinin, kīn(eîn) 'to move') is a peptide that promotes inflammation. It causes arterioles to dilate (enlarge) via the release of prostacyclin, nitric oxide, and endothelium-derived hyperpolarizing factor, and makes veins constrict via prostaglandin F2, thereby leading to leakage into capillary beds due to the increased pressure in the capillaries. Bradykinin consists of nine amino acids, and is a physiologically and pharmacologically active peptide of the kinin group of proteins.

Key facts

Protein.Band: 21
Protein.Name: kininogen 1
Protein.HGNCid: 6383
Protein.Symbol: KNG1
Protein.AltSymbols: KNG, BDK
Protein.EntrezGene: 3827
Protein.OMIM: 612358
Protein.RefSeq: NM_001102416
Protein.UniProt: P01042
Protein.Chromosome: 3
Protein.Arm: q
Protein.LocusSupplementaryData: -qter
Protein family.Symbol: Bradykinin
Protein family.Name: Bradykinin
Protein family.Pfam: PF06753
Protein family.InterPro: IPR009608

via Wikipedia infobox

Chemical data

Formula: C50H73N15O11
Molecular weight: 1060.2 g/mol
IUPAC name: (2S)-2-[[(2S)-2-[[(2S)-1-[(2S)-2-[[(2S)-2-[[2-[[(2S)-1-[(2S)-1-[(2S)-2-amino-5-(diaminomethylideneamino)pentanoyl]pyrrolidine-2-carbonyl]pyrrolidine-2-carbonyl]amino]acetyl]amino]-3-phenylpropanoyl]amino]-3-hydroxypropanoyl]pyrrolidine-2-carbonyl]amino]-3-phenylpropanoyl]amino]-5-(diaminomethylideneamino)pentanoic acid
SMILES: C1C[C@H](N(C1)C(=O)[C@@H]2CCCN2C(=O)[C@H](CCCN=C(N)N)N)C(=O)NCC(=O)N[C@@H](CC3=CC=CC=C3)C(=O)N[C@@H](CO)C(=O)N4CCC[C@H]4C(=O)N[C@@H](CC5=CC=CC=C5)C(=O)N[C@@H](CCCN=C(N)N)C(=O)O
InChIKey: QXZGBUJJYSLZLT-FDISYFBBSA-N
XLogP: -4.8
Polar surface area: 419 Å²
H-bond donors: 12
H-bond acceptors: 14
Formal charge: 0

via PubChem

Wikidata facts

Mass: 1059.561398

Show 4 more facts

chemical formula: C₅₀H₇₃N₁₅O₁₁
canonical SMILES: C1CC(N(C1)C(=O)C2CCCN2C(=O)C(CCCN=C(N)N)N)C(=O)NCC(=O)NC(CC3=CC=CC=C3)C(=O)NC(CO)C(=O)N4CCCC4C(=O)NC(CC5=CC=CC=C5)C(=O)NC(CCCN=C(N)N)C(=O)O
isomeric SMILES: C1C[C@H](N(C1)C(=O)[C@@H]2CCCN2C(=O)[C@H](CCCN=C(N)N)N)C(=O)NCC(=O)N[C@@H](CC3=CC=CC=C3)C(=O)N[C@@H](CO)C(=O)N4CCC[C@H]4C(=O)N[C@@H](CC5=CC=CC=C5)C(=O)N[C@@H](CCCN=C(N)N)C(=O)O
Commons category: Bradykinin

Sources (4)

via Wikidata · CC0

~8 min read

Article

11 sections

Contents

Structure
Metabolism
Function
Effects
Receptors
Disorders
Therapeutic implications
History
See also
References
Bibliography

{{chembox | Watchedfields = changed | verifiedrevid = 443425952 |ImageFile = Bradykinin structure.svg |ImageClass = skin-invert-image |ImageFile1 = Bradykinin updated.png |ImageClass1 = bg-transparent |ImageSize = 250px |ImageSize1 = 250px |IUPACName = Bradykinin |SystematicName=(2S)-2-{(12S,32S,9S,12S,142S,17S)-11-[(2S)-2-Amino-5-(carbamimidoylamino)pentanoyl]-9-benzyl-12-(hydroxymethyl)-2,4,7,10,13,15-hexaoxo-5,8,11,16-tetraaza-1(2),3,14(1,2)-tripyrrolidina-19-benzenanonadecaphane-17-carboxamido}-5-(carbamimidoylamino)pentanoic acid |OtherNames= |Section1= |Section2= }}