brivudine

Also known as 5-(2-bromovinyl)-2'-deoxyuridine

Brivudine (trade names Zostex, Mevir, Brivir, among others) is an antiviral drug used in the treatment of herpes zoster ("shingles"). Like other antivirals, it acts by inhibiting replication of the target virus.

Research

468 papers

Efficacy and safety of brivudine for the treatment of herpes zoster: a systematic review and meta-analysis.The Journal of dermatological treatment · 2024
Herpes zoster: A Review of Clinical Manifestations and Management.Viruses · 2022
Treatment with Brivudine in Immunocompromised Pediatric Patients with Herpes Zoster.Chemotherapy · 2023
Recommendations for the management of herpes zoster.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2007
Brivudine as a successful treatment for herpes zoster combined with chickenpox.Postepy dermatologii i alergologii · 2025

via PubMed

Wikidata facts

Mass: 332.001

Show 4 more facts

chemical formula: C₁₁H₁₃BrN₂O₅
canonical SMILES: C1C(C(OC1N2C=C(C(=O)NC2=O)C=CBr)CO)O
isomeric SMILES: C1[C@@H]([C@H](O[C@H]1N2C=C(C(=O)NC2=O)/C=C/Br)CO)O
Commons category: Brivudine

Sources (2)

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Article

15 sections

Contents

Medical uses
Contraindications
Adverse effects
Interactions
Pharmacology
Spectrum of activity
Mechanism of action
Pharmacokinetics
Chemistry
Manufacturing
History
Etymology
Research
See also
References

==Medical uses== Brivudine is used for the treatment of herpes zoster in adult patients. It is taken orally once daily, in contrast to aciclovir, valaciclovir and other antivirals. A study has found that it is more effective than aciclovir, but this has been disputed because of a possible conflict of interest on part of the study authors. While brivudine is approved in several European countries for the treatment of herpes zoster, it has not received approval in the USA or Canada. In these non-approving countries Sorivudine is preferred over Brivudine.