calcium sensing receptor

Protein · UniProt

Extracellular calcium-sensing receptor

Gene

CASR

Organism

Homo sapiens (Human)

Length

1,078 aa

Molecular mass

120,675 Da

Evidence

1: Evidence at protein level

G protein-coupled receptor that senses changes in the extracellular concentration of calcium ions and plays a key role in maintaining calcium homeostasis (PubMed:17555508, PubMed:19789209, PubMed:21566075, PubMed:22114145, PubMed:22789683, PubMed:23966241, PubMed:25104082, PubMed:25292184, PubMed:25766501, PubMed:26386835, PubMed:32817431, PubMed:33603117, PubMed:34194040, PubMed:34467854, PubMed:7759551, PubMed:8636323, PubMed:8702647, PubMed:8878438). Senses fluctuations in the circulating calcium concentration: activated by elevated circulating calcium, leading to decreased parathyroid h…

• Calcium-Sensing Receptor (CaSR)-Mediated Intracellular Communication in Cardiovascular Diseases.Cells · 2022
• Calcium-sensing receptor in the development and treatment of pulmonary hypertension.Molecular biology reports · 2021
• New insights into renal calcium-sensing receptor activation.Current opinion in nephrology and hypertension · 2024
• Calcium-sensing receptor and calcimimetic agents.Kidney international. Supplement · 1999
• Calcium-Sensing Receptor Expression in Breast Cancer.International journal of molecular sciences · 2023

via PubMed

• PHASE4COMPLETED
  The Study of Efficacy and Safety of REGPARA Drug in Dialysis Patients Have High Blood Levels of ParathyroidChulalongkorn University · NCT02056730
• NACOMPLETED
  Oral Peptones Load in Normocalcemic and Hypercalcemic Primary Hyperparathyroidism and Healthy SubjectsUniversity of Eastern Piedmont · NCT01042626
• PHASE3TERMINATED
  Effects of PTH Replacement on Bone in HypoparathyroidismNational Institute of Dental and Craniofacial Research (NIDCR) · NCT00395538
• NAUNKNOWN
  University of Wisconsin Solution Versus New Parathyroid Transport Solution for Parathyroid AllotransplantationSB Istanbul Education and Research Hospital · NCT03051308
• COMPLETED
  CR9112792, a Follow-up of Study CR9108963GlaxoSmithKline · NCT00891553
• NACOMPLETED
  The Expression of Matrix Metalloproteinase 13, Tissue Inhibitor of Metalloproteinases 3, and Calcium-sensing Receptor in Human Trabecular MeshworkLv Yingjuan · NCT02638181

via ClinicalTrials.gov

Wikidata facts

Instance of

protein

Part of

G protein-coupled recepteishon

via Wikidata · CC0