CAPN10
Sign in to saveAlso known as CANP10, NIDDM1, calpain 10
Calpain-10 is a protein that in humans is encoded by the CAPN10 gene.
Gene data
CAPN10- Name
- calpain 10
- Type
- protein-coding
- Position
- 240,586,366–240,618,845 (+)
- Aliases
- CANP10, NIDDM1
- Ensembl
- ENSG00000142330
- RefSeq RNA
- NM_021251.3, NM_023083.4, NM_023084.1, NM_023085.4, NM_023086.1
- RefSeq protein
- NP_075571.2, NP_075573.3
Calpains represent a ubiquitous, well-conserved family of calcium-dependent cysteine proteases. The calpain proteins are heterodimers consisting of an invariant small subunit and variable large subunits. The large catalytic subunit has four domains: domain I, the N-terminal regulatory domain that is processed upon calpain activation; domain II, the protease domain; domain III, a linker domain of unknown function; and domain IV, the calmodulin-like calcium-binding domain. This gene encodes a large subunit. It is an atypical calpain in that it lacks the calmodulin-like calcium-binding domain and instead has a divergent C-terminal domain. It is similar in organization to calpains 5 and 6. This gene is associated with type 2 or non-insulin-dependent diabetes mellitus (NIDDM), and is located within the NIDDM1 region. Multiple alternative transcript variants have been described for this gene. [provided by RefSeq, Sep 2010].
Gene Ontology
Biological process
Molecular function
Cellular component
Pathways
via MyGene.info
Gene · Ensembl
calpain 10
- Symbol
- CAPN10
- Biotype
- Protein coding
- Organism
- Homo sapiens
- Location
- 2:240,586,366-240,618,845
- Strand
- Forward (+)
- Assembly
- GRCh38
via Ensembl · EMBL-EBI
~1 min read
Encyclopedic overview
4 sectionsContents
- Overview
- References
- Further reading
- External links
Calpain-10 is a protein that in humans is encoded by the CAPN10 gene.
== Overview == Calpains are ubiquitous, well-conserved family of calcium-dependent, cysteine proteases. The typical calpain proteins are heterodimers consisting of an invariant small subunit and variable large subunits. The large catalytic subunit has four domains: domain I, the N-terminal regulatory domain that is processed upon calpain activation; domain II, the protease domain; domain III, a linker domain of unknown function; and domain IV, the calmodulin-like calcium-binding domain. The heterodimer interface is predominantly found between domain IV and the small subunit, which is also a calmodulin-like calcium-binding domain. This gene encodes a large subunit. It is an atypical calpain in that it lacks the calmodulin-like calcium-binding domain and instead has a divergent C-terminal domain. It therefore cannot heterodimerize with the small subunit. It is similar in organization to calpains 5 and 6. This gene is associated with type 2 or non-insulin-dependent diabetes mellitus (NIDDM) and located within the NIDDM1 region. Multiple alternative transcript variants encoding different isoforms have been described for this gene.
Excerpted from Wikipedia’s “CAPN10” article, available under the CC BY-SA 4.0 licence.