CTSK
Sign in to saveAlso known as CTS02, CTSO, CTSO1, CTSO2, PKND, PYCD, cathepsin K
protein-coding gene in the species Homo sapiens
Gene data
CTSK- Name
- cathepsin K
- Type
- protein-coding
- Position
- 150,794,880–150,809,577 (−)
- Aliases
- CTS02, CTSO, CTSO1, CTSO2, PKND, PYCD
- Ensembl
- ENSG00000143387
- RefSeq RNA
- NM_000396.4
- RefSeq protein
- NP_000387.1
The protein encoded by this gene is a lysosomal cysteine proteinase involved in bone remodeling and resorption. This protein, which is a member of the peptidase C1 protein family, is predominantly expressed in osteoclasts. However, the encoded protein is also expressed in a significant fraction of human breast cancers, where it could contribute to tumor invasiveness. Mutations in this gene are the cause of pycnodysostosis, an autosomal recessive disease characterized by osteosclerosis and short stature. [provided by RefSeq, Apr 2013].
Gene Ontology
Biological process
Molecular function
Pathways
Lysosome - Homo sapiens (human)Apoptosis - Homo sapiens (human)Osteoclast differentiation - Homo sapiens (human)Toll-like receptor signaling pathway - Homo sapiens (human)Rheumatoid arthritis - Homo sapiens (human)Adaptive Immune SystemCollagen degradationDegradation of the extracellular matrixExtracellular matrix organizationActivation of Matrix Metalloproteinases
via MyGene.info
Gene · Ensembl
cathepsin K
- Symbol
- CTSK
- Biotype
- Protein coding
- Organism
- Homo sapiens
- Location
- 1:150,794,880-150,809,577
- Strand
- Reverse (−)
- Assembly
- GRCh38
View on Ensembl →
via Ensembl · EMBL-EBI