caryophyllene
Sign in to saveCaryophyllene (), more formally (−)-β-caryophyllene (BCP), is a natural bicyclic sesquiterpene that occurs widely in nature. Caryophyllene is notable for having a cyclobutane ring, as well as a trans-double bond in a 9-membered ring, both rarities in nature.
Research
4,146 papers- Beta-caryophyllene in psychiatric and neurological diseases: Role of blood-brain barrier.Vitamins and hormones · 2024
- β-Caryophyllene suppresses ferroptosis induced by cerebral ischemia reperfusion via activation of the NRF2/HO-1 signaling pathway in MCAO/R rats.Phytomedicine : international journal of phytotherapy and phytopharmacology · 2022
- Beta-Caryophyllene, a Cannabinoid Receptor Type 2 Selective Agonist, in Emotional and Cognitive Disorders.International journal of molecular sciences · 2024
- β-caryophyllene Delivery Systems: Enhancing the Oral Pharmacokinetic and Stability.Current pharmaceutical design · 2018
- Protective Effects of (E)-β-Caryophyllene (BCP) in Chronic Inflammation.Nutrients · 2020
via PubMed
Article
9 sectionsContents
- Production
- Basic research
- Safety
- Metabolism and derivatives
- Natural sources
- Biosynthesis
- Compendial status
- Further reading
- Notes and references
Caryophyllene (), more formally (−)-β-caryophyllene (BCP), is a natural bicyclic sesquiterpene that occurs widely in nature. Caryophyllene is notable for having a cyclobutane ring, as well as a trans-double bond in a 9-membered ring, both rarities in nature.
== Production == Caryophyllene can be produced synthetically, but it is invariably obtained from natural sources because it is widespread. It is a constituent of many essential oils, especially clove oil, the oil from the stems and flowers of Syzygium aromaticum (cloves), the essential oil of Cannabis sativa, copaiba, rosemary, and hops. It is usually found as a mixture with isocaryophyllene (the cis double bond isomer) and α-humulene (obsolete name: α-caryophyllene), a ring-opened isomer.