CCDC88A

Name

coiled-coil and HOOK domain protein 88A

Type

protein-coding

Aliases

APE, GIRDIN, GIV, GRDN, HkRP1, KIAA1212, PEHO, PEHOL

This gene encodes a member of the Girdin family of coiled-coil domain containing proteins. The encoded protein is an actin-binding protein that is activated by the serine/threonine kinase Akt and plays a role in cytoskeleton remodeling and cell migration. The encoded protein also enhances Akt signaling by mediating phosphoinositide 3-kinase (PI3K)-dependent activation of Akt by growth factor receptor tyrosine kinases and G protein-coupled receptors. Increased expression of this gene and phosphorylation of the encoded protein may play a role in cancer metastasis. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Dec 2011].

via MyGene.info

Wikidata facts

via Wikidata · CC0