CDC25B
Sign in to saveAlso known as cell division cycle 25B
M-phase inducer phosphatase 2 is an enzyme that in humans is encoded by the CDC25B gene.
Gene data
CDC25B- Name
- cell division cycle 25B
- Type
- protein-coding
- Position
- 3,786,772–3,806,730 (+)
- Aliases
- MPIP2
- Ensembl
- ENSG00000101224
- RefSeq RNA
- NM_001287516.2, NM_001287517.2, NM_001287518.2, NM_001287519.2, NM_001287520.2
- RefSeq protein
- NP_001274445.1, NP_001274446.1, NP_001274447.1, NP_001274448.1, NP_001274449.1
CDC25B is a member of the CDC25 family of phosphatases. CDC25B activates the cyclin dependent kinase CDC2 by removing two phosphate groups and it is required for entry into mitosis. CDC25B shuttles between the nucleus and the cytoplasm due to nuclear localization and nuclear export signals. The protein is nuclear in the M and G1 phases of the cell cycle and moves to the cytoplasm during S and G2. CDC25B has oncogenic properties, although its role in tumor formation has not been determined. Multiple transcript variants for this gene exist. [provided by RefSeq, Jul 2008].
Gene Ontology
Biological process
Molecular function
Pathways
via MyGene.info
Gene · Ensembl
cell division cycle 25B
- Symbol
- CDC25B
- Biotype
- Protein coding
- Organism
- Homo sapiens
- Location
- 20:3,786,772-3,806,730
- Strand
- Forward (+)
- Assembly
- GRCh38
via Ensembl · EMBL-EBI
Research
728 papers- CDC25B Inhibition by Menadione: A Potential New Therapeutical Approach.Anti-cancer agents in medicinal chemistry · 2022
- CDC25B is required for the metaphase I-metaphase II transition in mouse oocytes.Journal of cell science · 2022
- CDC25B Is a Prognostic Biomarker Associated With Immune Infiltration and Drug Sensitivity in Hepatocellular Carcinoma.International journal of genomics · 2024
- Cdc25B phosphatase inhibitors in cancer therapy: latest developments, trends and medicinal chemistry perspective.Anti-cancer agents in medicinal chemistry · 2008
- CDC25B and CDC25C overexpression in nonmelanoma skin cancer suppresses cell death.Molecular carcinogenesis · 2019
via PubMed
Wikidata facts
- Instance of
- gene
- Image
- Protein CDC25B PDB 1cwr.png
Show 8 more facts
- HomoloGene ID
- 41451
- found in taxon
- Homo sapiens
- exact match
- identifiers.org/ncbigene/994
- genomic end
- 3786762
- genomic start
- 3767578
- chromosome
- human chromosome 20
- cytogenetic location
- 20p13
- expressed in
- anterior pituitary
Sources (4)
via Wikidata · CC0
~1 min read
Encyclopedic overview
4 sectionsContents
- Interactions
- References
- Further reading
- External links
M-phase inducer phosphatase 2 is an enzyme that in humans is encoded by the CDC25B gene.
CDC25B is a member of the CDC25 family of phosphatases. CDC25B activates the cyclin dependent kinase CDC2 by removing two phosphate groups and it is required for entry into mitosis. CDC25B shuttles between the nucleus and the cytoplasm due to nuclear localization and nuclear export signals. The protein is nuclear in the M and G1 phases of the cell cycle and moves to the cytoplasm during S and G2. CDC25B has oncogenic properties, although its role in tumor formation has not been determined. Multiple transcript variants for this gene exist.
Excerpted from Wikipedia’s “CDC25B” article, available under the CC BY-SA 4.0 licence.