MAPK9

Name

mitogen-activated protein kinase 9

Type

protein-coding

Position

180,233,143–180,292,107 (−)

Aliases

JNK-55, JNK2, JNK2A, JNK2ALPHA, JNK2B, JNK2BETA, PRKM9, SAPK, SAPK1a, p54a

Ensembl

ENSG00000050748

RefSeq RNA

NM_001135044.2, NM_001308244.1, NM_001364607.2, NM_001364608.2, NM_001364609.2

RefSeq protein

NP_001128516.1, NP_001295173.1, NP_001351536.1, NP_001351537.1, NP_001351538.1

The protein encoded by this gene is a member of the MAP kinase family. MAP kinases act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. This kinase targets specific transcription factors, and thus mediates immediate-early gene expression in response to various cell stimuli. It is most closely related to MAPK8, both of which are involved in UV radiation induced apoptosis, thought to be related to the cytochrome c-mediated cell death pathway. This gene and MAPK8 are also known as c-Jun N-terminal kinases. This kinase blocks the ubiquitination of tumor suppressor p53, and thus it increases the stability of p53 in nonstressed cells. Studies of this gene's mouse counterpart suggest a key role in T-cell differentiation. Several alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Sep 2008].

via MyGene.info

Gene · Ensembl

mitogen-activated protein kinase 9

Symbol

MAPK9

Biotype

Protein coding

Organism

Homo sapiens

Location

5:180,233,143-180,292,107

Strand

Reverse (−)

Assembly

GRCh38