CDKN1B
Sign in to saveAlso known as CDKN4, KIP1, MEN1B, MEN4, P27KIP1, cyclin-dependent kinase inhibitor 1B, cyclin dependent kinase inhibitor 1B
Gen der Spezies Homo sapiens
Gene data
CDKN1B- Name
- cyclin dependent kinase inhibitor 1B
- Type
- protein-coding
- Position
- 12,685,498–12,722,373 (+)
- Aliases
- CDKN4, KIP1, MEN1B, MEN4, P27KIP1
- Ensembl
- ENSG00000111276
- RefSeq RNA
- NM_004064.5
- RefSeq protein
- NP_004055.1
This gene encodes a cyclin-dependent kinase inhibitor, which shares a limited similarity with CDK inhibitor CDKN1A/p21. The encoded protein binds to and prevents the activation of cyclin E-CDK2 or cyclin D-CDK4 complexes, and thus controls the cell cycle progression at G1. The degradation of this protein, which is triggered by its CDK dependent phosphorylation and subsequent ubiquitination by SCF complexes, is required for the cellular transition from quiescence to the proliferative state. Mutations in this gene are associated with multiple endocrine neoplasia type IV (MEN4). [provided by RefSeq, Apr 2014].
Gene Ontology
Biological process
Molecular function
Cellular component
Pathways
via MyGene.info
Gene · Ensembl
cyclin dependent kinase inhibitor 1B
- Symbol
- CDKN1B
- Biotype
- Protein coding
- Organism
- Homo sapiens
- Location
- 12:12,685,498-12,722,373
- Strand
- Forward (+)
- Assembly
- GRCh38
via Ensembl · EMBL-EBI
Wikidata facts
- Instance of
- gene
- Image
- Cyclin-dependent kinase inhibitor 1B within CDK2 - Cyclin A2 - CDKN1B complex 1JSU.png
Show 8 more facts
- HomoloGene ID
- 2999
- found in taxon
- Homo sapiens
- exact match
- identifiers.org/ncbigene/1027
- genomic end
- 12722369
- genomic start
- 12685498
- chromosome
- human chromosome 12
- cytogenetic location
- 12p13.1
- expressed in
- cerebellar vermis
Sources (7)
via Wikidata · CC0