Structure via PubChem · Public domain (PubChem)
lovastatin
Sign in to saveAlso known as Lovastatine, Lovastatinum, Lovastatina, Mevinolin, (1S,3R,7S,8S,8aR)-1,2,3,7,8,8a-hexahydro-3,7-dimethyl-8-(2-(2R,4R)-(tetrahydro-4-hydroxy-6-oxo-2H-pyran-2-yl)ethyl)-1-naphthalenyl (S)-2-methyl-butyrate, 2β,6α-dimethyl-8alpha-(2-methyl-1-oxobutoxy)-mevinic acid lactone, 6alpha-methylcompactin, 6α-methylcompactin
Lovastatin, sold under the brand name Mevacor among others, is a statin medication, to treat high blood cholesterol and reduce the risk of cardiovascular disease. Its use is recommended together with lifestyle changes. It is taken by mouth.
Key facts
- Drug.width
- 200
- Drug.width2
- 250
- Drug.Watchedfields
- changed
- Drug.verifiedrevid
- 458448510
- Drug.image
- Lovastatin.svg
- Drug.image_class
- skin-invert-image
- Drug.tradename
- Mevacor, Altocor, others
- Drug.MedlinePlus
- a688006
- Drug.DailyMedID
- Lovastatin
- Drug.routes_of_administration
- By mouth
- Drug.ATC_prefix
- C10
- Drug.ATC_suffix
- AA02
- Drug.legal_US
- Rx-only
- Drug.bioavailability
- <5%
- Drug.protein_bound
- >98%
- Drug.metabolism
- Liver (CYP3A and CYP2C8 substrate)
- Drug.elimination_half life
- 2–5 hours
- Drug.excretion
- Faeces (83%), urine (10%)
via Wikipedia infobox
Chemical data
- Formula
- C24H36O5
- Molecular weight
- 404.5 g/mol
- IUPAC name
- [(1S,3R,7S,8S,8aR)-8-[2-[(2R,4R)-4-hydroxy-6-oxooxan-2-yl]ethyl]-3,7-dimethyl-1,2,3,7,8,8a-hexahydronaphthalen-1-yl] (2S)-2-methylbutanoate
- SMILES
- CC[C@H](C)C(=O)O[C@H]1C[C@H](C=C2[C@H]1[C@H]([C@H](C=C2)C)CC[C@@H]3C[C@H](CC(=O)O3)O)C
- InChIKey
- PCZOHLXUXFIOCF-BXMDZJJMSA-N
- XLogP
- 4.3
- Polar surface area
- 72.8 Ų
- H-bond donors
- 1
- H-bond acceptors
- 5
- Formal charge
- 0
via PubChem
Research
14,093 papers- Lovastatin for hypercholesterolemia.Drug intelligence & clinical pharmacy · 1988
- Lovastatin alleviates DSS-induced colitis by modulating macrophage polarization via the PPARγ-NF-κB pathway.International immunopharmacology · 2025
- Lovastatin: a new cholesterol-lowering agent.Pharmacotherapy · 1987
- Lovastatin production: From molecular basis to industrial process optimization.Biotechnology advances · 2015
- Lovastatin extended release: a review of its use in the management of hypercholesterolaemia.Drugs · 2003
via PubMed
Wikidata facts
- Mass
- 404.256
Show 6 more facts
- chemical formula
- C₂₄H₃₆O₅
- canonical SMILES
- CCC(C)C(=O)OC1CC(C=C2C1C(C(C=C2)C)CCC3CC(CC(=O)O3)O)C
- isomeric SMILES
- CC[C@H](C)C(=O)O[C@H]1C[C@H](C=C2[C@H]1[C@H]([C@H](C=C2)C)CC[C@@H]3C[C@H](CC(=O)O3)O)C
- defined daily dose
- 45
- Commons category
- Lovastatin
- melting point
- 175
via Wikidata · CC0
~14 min read
Article
13 sectionsContents
- Medical uses
- Side effects
- Contraindications
- Interactions
- Mechanism of action
- History
- Biosynthesis
- Total synthesis
- Society and culture
- Natural sources
- Brand names
- Other applications
- References
{{Infobox drug | Watchedfields = changed | verifiedrevid = 458448510 | image = Lovastatin.svg | image_class = skin-invert-image | width = 200 | alt = | image2 = | width2 = 250 | alt2 = | caption =
| pronounce = | tradename = Mevacor, Altocor, others | Drugs.com = | MedlinePlus = a688006 | DailyMedID = Lovastatin | pregnancy_AU = | pregnancy_AU_comment = | pregnancy_category= | routes_of_administration = By mouth | class = | ATC_prefix = C10 | ATC_suffix = AA02 | ATC_supplemental =