TP63
Sign in to saveTumor protein p63, typically referred to as p63, also known as transformation-related protein 63, is a protein that in humans is encoded by the TP63 (also known as the p63) gene.
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- Instance of
- gene
- Image
- Protein TP73L PDB 1rg6.png
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- P703
- Homo sapiens
- P1057
- human chromosome 3
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Article
12 sectionsContents
- Function
- Oocyte integrity
- Clinical significance
- Molecular mechanism
- Vulvar cancer
- Diagnostic utility
- Interactions
- Regulation
- See also
- References
- Further reading
- External links
Tumor protein p63, typically referred to as p63, also known as transformation-related protein 63, is a protein that in humans is encoded by the TP63 (also known as the p63) gene.
The TP63 gene was discovered 20 years after the discovery of the p53 tumor suppressor gene and along with p73 constitutes the p53 gene family based on their structural similarity. Despite being discovered significantly later than p53, phylogenetic analysis of p53, p63 and p73, suggest that p63 was the original member of the family from which p53 and p73 evolved.