SKP2

Also known as FBL1, FBXL1, FLB1, p45, S-phase kinase-associated protein 2, E3 ubiquitin protein ligase, S-phase kinase associated protein 2

S-phase kinase-associated protein 2 is an enzyme that in humans is encoded by the SKP2 gene.

Gene data

SKP2

Name: S-phase kinase associated protein 2
Type: protein-coding
Position: 36,151,989–36,196,849 (+)
Aliases: FBL1, FBXL1, FLB1, p45
Ensembl: ENSG00000145604
RefSeq RNA: NM_001243120.2, NM_005983.4, NM_032637.4, XM_047417536.1, XM_054353187.1
RefSeq protein: NP_001230049.1, NP_005974.2, NP_116026.1, XP_047273492.1, XP_054209162.1

This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbls class; in addition to an F-box, this protein contains 10 tandem leucine-rich repeats. This protein is an essential element of the cyclin A-CDK2 S-phase kinase. It specifically recognizes phosphorylated cyclin-dependent kinase inhibitor 1B (CDKN1B, also referred to as p27 or KIP1) predominantly in S phase and interacts with S-phase kinase-associated protein 1 (SKP1 or p19). In addition, this gene is established as a protooncogene causally involved in the pathogenesis of lymphomas. Alternative splicing of this gene generates three transcript variants encoding different isoforms. [provided by RefSeq, Jul 2011].