Cetiedil
Sign in to saveCetiedil is a vasodilator and an anti-sickling agent. ==Synthesis== [[File:Cetiedil synthesis.svg|thumb|center|550px|Thieme Original patents: Prepn and activity: Revised synthesis: Analogues:]] The Clemmensen reduction of 3-thienylcyclohexyl-glycolic acid, CID:11064522 (1) gives cyclohexyl(thiophen-3-yl)acetic acid [16199-74-9] (2). Esterification of the sodium salt of the resulting acid with 1-(2-chloroethyl)azepane [2205-31-4] (3) produces cetiedil (4). == References ==
Research
88 papers- Cetiedil, a drug that inhibits acetylcholine release in Torpedo electric organ.Journal of neurochemistry · 1987
- An analysis of the mechanism by which cetiedil inhibits sickling.Life sciences · 2002
- A collaborative, double-blind randomized study of cetiedil citrate in sickle cell crisis.Blood · 1986
- Effect of cetiedil on cation and water movements in erythrocytes.The Journal of clinical investigation · 1982
- An analysis of the mechanism by which cetiedil inhibits the Gardos phenomenon.American journal of hematology · 1984
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Encyclopedic overview
2 sectionsContents
- Synthesis
- References
Cetiedil is a vasodilator and an anti-sickling agent. ==Synthesis== [[File:Cetiedil synthesis.svg|thumb|center|550px|Thieme Original patents: Prepn and activity: Revised synthesis: Analogues:]] The Clemmensen reduction of 3-thienylcyclohexyl-glycolic acid, CID:11064522 (1) gives cyclohexyl(thiophen-3-yl)acetic acid [16199-74-9] (2). Esterification of the sodium salt of the resulting acid with 1-(2-chloroethyl)azepane [2205-31-4] (3) produces cetiedil (4). == References ==
Category:Thiophenes Category:Carboxylate esters Category:Azepanes Category:Cyclohexyl compounds
Excerpted from Wikipedia’s “Cetiedil” article, available under the CC BY-SA 4.0 licence.