Structure via PubChem · Public domain (PubChem)
cyclandelate
Sign in to saveAlso known as Cyclospasmol, 3,5,5-Trimethylcyclohexyl amygdalate, 3,3,5-Trimethylcyclohexyl mandelate, Ciclandelato, Cyclandelatum
Cyclandelate is a vasodilator used in the treatment of claudication, arteriosclerosis and Raynaud's disease. It is also used to treat nighttime leg cramps, and has been investigated for its effect against migraine. It is orally administered.
Chemical data
- Formula
- C17H24O3
- Molecular weight
- 276.4 g/mol
- IUPAC name
- (3,3,5-trimethylcyclohexyl) 2-hydroxy-2-phenylacetate
- SMILES
- CC1CC(CC(C1)(C)C)OC(=O)C(C2=CC=CC=C2)O
- InChIKey
- WZHCOOQXZCIUNC-UHFFFAOYSA-N
- XLogP
- 4.2
- Polar surface area
- 46.5 Ų
- H-bond donors
- 1
- H-bond acceptors
- 3
- Formal charge
- 0
via PubChem
Drug data · ChEMBL
- Max clinical phase
- Approved
- Molecule type
- Small molecule
- Indications
- cardiovascular disease
via ChEMBL · EBI
Research
190 papers- Cyclandelate.British medical journal · 1967
- Cyclandelate versus propranolol in the prophylaxis of migraine--a double-blind placebo-controlled study.Functional neurology · 1995
- Cyclandelate in the prophylaxis of migraine: a placebo-controlled study.Cephalalgia : an international journal of headache · 2001
- Cyclandelate in the prophylaxis of migraine: a randomized, parallel, double-blind study in comparison with placebo and propranolol. The Study group.Cephalalgia : an international journal of headache · 1996
- Cyclandelate in the management of tinnitus: a randomized, placebo-controlled study.Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery · 1998
via PubMed
Wikidata facts
- Subclass of
- chemical compound
- Mass
- 276.172545
- Has use
- medication
Show 6 more facts
- chemical formula
- C₁₇H₂₄O₃
- canonical SMILES
- CC1CC(CC(C1)(C)C)OC(=O)C(C2=CC=CC=C2)O
- World Health Organisation international non-proprietary name
- cyclandelate
- defined daily dose
- 0.6
- subject has role
- vasodilator agent
- medical condition treated
- intermittent claudication
via Wikidata · CC0
~1 min read
Encyclopedic overview
1 sectionsContents
- References
Cyclandelate is a vasodilator used in the treatment of claudication, arteriosclerosis and Raynaud's disease. It is also used to treat nighttime leg cramps, and has been investigated for its effect against migraine. It is orally administered.
==References==
Excerpted from Wikipedia’s “cyclandelate” article, available under the CC BY-SA 4.0 licence.
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