CHEK1
Sign in to saveAlso known as CHK1, checkpoint kinase 1
Checkpoint kinase 1, commonly referred to as Chk1, is a serine/threonine-specific protein kinase that, in humans, is encoded by the CHEK1 gene. Chk1 coordinates the DNA damage response (DDR) and cell cycle checkpoint response. Activation of Chk1 results in the initiation of cell cycle checkpoints, cell cycle arrest, DNA repair and cell death to prevent damaged cells from progressing through the cell cycle.
Gene data
CHEK1- Name
- checkpoint kinase 1
- Type
- protein-coding
- Position
- 125,625,163–125,676,255 (+)
- Aliases
- CHK1, OZEMA21
- Ensembl
- ENSG00000149554
- RefSeq RNA
- NM_001114121.2, NM_001114122.3, NM_001244846.1, NM_001274.5, NM_001330427.2
- RefSeq protein
- NP_001107593.1, NP_001107594.1, NP_001231775.1, NP_001265.2, NP_001317356.2
The protein encoded by this gene belongs to the Ser/Thr protein kinase family. It is required for checkpoint mediated cell cycle arrest in response to DNA damage or the presence of unreplicated DNA. This protein acts to integrate signals from ATM and ATR, two cell cycle proteins involved in DNA damage responses, that also associate with chromatin in meiotic prophase I. Phosphorylation of CDC25A protein phosphatase by this protein is required for cells to delay cell cycle progression in response to double-strand DNA breaks. Several alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Oct 2011].
Gene Ontology
Biological process
Molecular function
Pathways
via MyGene.info
Gene · Ensembl
checkpoint kinase 1
- Symbol
- CHEK1
- Biotype
- Protein coding
- Organism
- Homo sapiens
- Location
- 11:125,625,163-125,676,255
- Strand
- Forward (+)
- Assembly
- GRCh38
via Ensembl · EMBL-EBI
Wikidata facts
- Image
- Protein CHEK1 PDB 1ia8.png
Show 5 more facts
- HomoloGene ID
- 975
- exact match
- identifiers.org/ncbigene/1111
- genomic end
- 125546150
- genomic start
- 125625163
- cytogenetic location
- 11q24.2
via Wikidata · CC0
~10 min read
Article
16 sectionsContents
- Discovery
- Structure
- Function
- S phase
- G2/M transition
- M phase
- Interactions
- Chk1 activation
- Cell cycle arrest
- DNA repair
- Clinical relevance
- Meiosis
- See also
- References
- Further reading
- External links
Checkpoint kinase 1, commonly referred to as Chk1, is a serine/threonine-specific protein kinase that, in humans, is encoded by the CHEK1 gene. Chk1 coordinates the DNA damage response (DDR) and cell cycle checkpoint response. Activation of Chk1 results in the initiation of cell cycle checkpoints, cell cycle arrest, DNA repair and cell death to prevent damaged cells from progressing through the cell cycle.
==Discovery== In 1993, Beach and associates initially identified Chk1 as a serine/threonine kinase which regulates the G2/M phase transition in fission yeast. Constitutive expression of Chk1 in fission yeast was shown to induce cell cycle arrest. The same gene called Rad27 was identified in budding yeast by Carr and associates. In 1997, homologs were identified in more complex organisms including the fruit fly, human and mouse. Through these findings, it is apparent Chk1 is highly conserved from yeast to humans.