chemokine
Sign in to saveChemokines (), or chemotactic cytokines, are a family of small cytokines or signaling proteins secreted by cells that induce directional movement of leukocytes, as well as other cell types, including endothelial and epithelial cells. In addition to playing a major role in the activation of host immune responses, chemokines are important for biological processes, including morphogenesis and wound healing, as well as in the pathogenesis of diseases like cancers.
Key facts
- Protein family.PDB
- A:24-90 :24-90 A:24-90 B:29-90 D:24-90 B:24-90 24-90 B:24-90 A:24-90 24-88 :24-88 A:27-89 A:27-89 A:24-89 A:24-89 A:24-89 B:24-88 B:24-88 B:26-88 B:24-88 D:24-88 B:24-88 B:24-88 B:25-88 A:24-88 A:24-88 A:24-88 A:45-109 :48-108 A:26-91 A:26-89 B:26-89 A:26-89 A:26-89 A:26-89 A:26-33 A:24-88 A:24-88 A:23-84 A:23-84 A:24-88 A:24-88 A:24-88 B:26-89 A:26-89 A:27-89 A:28-90 A:29-93 A:28-93 A:28-93 :31-93 32-93 :31-93 B:34-93 B:28-93 B:29-93 C:61-121 D:59-121 A:54-121 B:35-101 A:35-101 A:35-101 A:28-94 D:38-98 B:32-98 C:39-98 D:32-98 A:39-98 D:32-98 A:87-98 D:21-82 A:22-89 B:22-89 B:22-89 A:22-89 A:22-89 :22-87 B:22-87 B:29-85 :22-87 A:22-87
- Protein family.Symbol
- IL8
- Protein family.Name
- Small cytokines (intecrine/chemokine), interleukin-8 like
- Protein family.image
- IL8 Solution Structure.rsh.png
- Protein family.caption
- Solution structure of interleukin-8, a chemokine of the CXC subfamily
- Protein family.Pfam
- PF00048
- Protein family.InterPro
- IPR001811
- Protein family.Prosite
- PDOC00434
- Protein family.SCOP
- 3il8
via Wikipedia infobox
Article
16 sectionsContents
- Function
- Types by function
- Homing
- Types by cell attracted
- Structural characteristics
- Types by structure
- CC chemokines
- CXC chemokines
- C chemokines
- CX<sub>3</sub>C chemokines
- Receptors
- Signal transduction
- Infection control
- See also
- References
- External links
Chemokines (), or chemotactic cytokines, are a family of small cytokines or signaling proteins secreted by cells that induce directional movement of leukocytes, as well as other cell types, including endothelial and epithelial cells. In addition to playing a major role in the activation of host immune responses, chemokines are important for biological processes, including morphogenesis and wound healing, as well as in the pathogenesis of diseases like cancers.
Cytokine proteins are classified as chemokines according to behavior and structural characteristics. In addition to being known for mediating chemotaxis, chemokines are all approximately 8–10 kilodaltons in mass and have four cysteine residues in conserved locations that are key to forming their 3-dimensional shape.