Chemokine (C motif) ligand 1 also known as lymphotactin is a protein that in humans is encoded by the XCL1 gene. XCL1 is a small cytokine belonging to the C chemokine family that signals exclusively through its receptor XCR1. Produced primarily by activated CD8+ T cells and natural killer (NK) cells, XCL1 functions as a chemoattractant for specific immune cell populations, particularly XCR1-positive conventional dendritic cells (cDC1s), thereby orchestrating immune responses to infection and inflammation.
Chemokine (C motif) ligand 1 also known as lymphotactin is a protein that in humans is encoded by the XCL1 gene. XCL1 is a small cytokine belonging to the C chemokine family that signals exclusively through its receptor XCR1. Produced primarily by activated CD8+ T cells and natural killer (NK) cells, XCL1 functions as a chemoattractant for specific immune cell populations, particularly XCR1-positive conventional dendritic cells (cDC1s), thereby orchestrating immune responses to infection and inflammation.
Chemokines are known for their function in inflammatory and immunological responses. This family C chemokines differs in structure and function from most chemokines. There are only two chemokines in this family and what separates them from other chemokines is that they only have two cysteines; one N-terminal cysteine and one cysteine downstream. These both are called lymphotactin, alpha and beta form, and claim special characteristics only found between the two. Lymphotactins can go through a reversible conformational change which influences its binding.
Discovered by embedding cosine similarity (sentence-transformers MiniLM, 384-dim).