XCL1
Sign in to saveAlso known as ATAC, LPTN, LTN, SCM-1, SCM-1a, SCM1, SCM1A, SCYC1
Chemokine (C motif) ligand 1 also known as lymphotactin is a protein that in humans is encoded by the XCL1 gene. XCL1 is a small cytokine belonging to the C chemokine family that signals exclusively through its receptor XCR1. Produced primarily by activated CD8+ T cells and natural killer (NK) cells, XCL1 functions as a chemoattractant for specific immune cell populations, particularly XCR1-positive conventional dendritic cells (cDC1s), thereby orchestrating immune responses to infection and inflammation.
Gene data
XCL1- Name
- X-C motif chemokine ligand 1
- Type
- protein-coding
- Position
- 168,576,596–168,582,069 (+)
- Aliases
- ATAC, LPTN, LTN, SCM-1, SCM-1a, SCM1, SCM1A, SCYC1
- Ensembl
- ENSG00000143184
- RefSeq RNA
- NM_002995.3, XM_054338141.1
- RefSeq protein
- NP_002986.1, XP_054194116.1
This antimicrobial gene encodes a member of the chemokine superfamily. Chemokines function in inflammatory and immunological responses, inducing leukocyte migration and activation. The encoded protein is a member of the C-chemokine subfamily, retaining only two of four cysteines conserved in other chemokines, and is thought to be specifically chemotactic for T cells. This gene and a closely related family member are located on the long arm of chromosome 1. [provided by RefSeq, Sep 2014].
Gene Ontology
Biological process
Molecular function
Pathways
via MyGene.info
Gene · Ensembl
X-C motif chemokine ligand 1
- Symbol
- XCL1
- Biotype
- Protein coding
- Organism
- Homo sapiens
- Location
- 1:168,576,596-168,582,069
- Strand
- Forward (+)
- Assembly
- GRCh38
via Ensembl · EMBL-EBI
Wikidata facts
- Instance of
- gene
Show 7 more facts
- found in taxon
- Homo sapiens
- HomoloGene ID
- 2250
- exact match
- identifiers.org/ncbigene/6375
- chromosome
- human chromosome 1
- genomic end
- 168582069
- genomic start
- 168576605
- cytogenetic location
- 1q24.2
Sources (4)
via Wikidata · CC0
~5 min read
Encyclopedic overview
6 sectionsContents
- Gene
- Tissue distribution
- Structure
- Function
- Clinical significance
- References
Chemokine (C motif) ligand 1 also known as lymphotactin is a protein that in humans is encoded by the XCL1 gene. XCL1 is a small cytokine belonging to the C chemokine family that signals exclusively through its receptor XCR1. Produced primarily by activated CD8+ T cells and natural killer (NK) cells, XCL1 functions as a chemoattractant for specific immune cell populations, particularly XCR1-positive conventional dendritic cells (cDC1s), thereby orchestrating immune responses to infection and inflammation.
Chemokines are known for their function in inflammatory and immunological responses. This family C chemokines differs in structure and function from most chemokines. There are only two chemokines in this family and what separates them from other chemokines is that they only have two cysteines; one N-terminal cysteine and one cysteine downstream. These both are called lymphotactin, alpha and beta form, and claim special characteristics only found between the two. Lymphotactins can go through a reversible conformational change which influences its binding.
Excerpted from Wikipedia’s “XCL1” article, available under the CC BY-SA 4.0 licence.