cholinesterase
Sign in to saveAlso known as non-specific cholinesterase, choline esterase, ChE
The enzyme cholinesterase (EC 3.1.1.8, choline esterase; systematic name acylcholine acylhydrolase) catalyses the hydrolysis of choline-based esters, several of which serve as neurotransmitters.:
Key facts
- Protein.Symbol
- BCHE
- Protein.Name
- butyrylcholinesterase
- Protein.caption
- Cartoon diagram of human butyrylcholinesterase. From .
- Protein.image
- Butyrylcholinesterase 1P0I.png
- Protein.width
- 200
- Protein.HGNCid
- 983
- Protein.AltSymbols
- CHE1, CHE2, E1
- Protein.EntrezGene
- 590
- Protein.OMIM
- 177400
- Protein.RefSeq
- NM_000055
- Protein.UniProt
- P06276
- Protein.ECnumber
- 3.1.1.8
- Protein.Chromosome
- 3
- Protein.Arm
- q
- Protein.Band
- 26.1
- Protein.LocusSupplementaryData
- -26.2
via Wikipedia infobox
Research
62,481 papers- Cholinesterase-based biosensors.Journal of enzyme inhibition and medicinal chemistry · 2016
- Cholinesterase and succinylcholine.Danish medical bulletin · 1983
- Pharmacogenetics. Cholinesterase variants and suxamethonium apnoea.Proceedings of the Royal Society of Medicine · 1968
- Pseudo-cholinesterase.British medical bulletin · 1961
- Cholinesterase. Its significance in anaesthetic practice.Anaesthesia · 1997
via PubMed
~7 min read
Encyclopedic overview
7 sectionsContents
- Types and nomenclature
- Discovery
- Clinical significance
- Inhibitors
- Additional images
- References
- External links
The enzyme cholinesterase (EC 3.1.1.8, choline esterase; systematic name acylcholine acylhydrolase) catalyses the hydrolysis of choline-based esters, several of which serve as neurotransmitters.: an acylcholine + H2O = choline + a carboxylate
These reactions are necessary to allow a cholinergic neuron to return to its resting state after activation. For example, in muscle contraction, acetylcholine at a neuromuscular junction triggers a contraction; but for the muscle to relax afterward, rather than remaining locked in a tense state, the acetylcholine must be broken down by a choline esterase.
Excerpted from Wikipedia’s “cholinesterase” article, available under the CC BY-SA 4.0 licence.