Coagulation factor VIII

Protein · UniProt

Coagulation factor VIII

Gene

F8

Organism

Homo sapiens (Human)

Length

2,351 aa

Molecular mass

267,009 Da

Evidence

1: Evidence at protein level

Factor VIII, along with calcium and phospholipid, acts as a cofactor for F9/factor IXa when it converts F10/factor X to the activated form, factor Xa

• Coagulation factor VIII: biological basis of emerging hemophilia A therapies.Blood · 2024
• Management of coagulation factor VIII (FVIII) inhibitors.Thrombosis research · 2019
• Coagulation factor VIII: structure and stability.International journal of pharmaceutics · 2003
• Blood coagulation factor VIII: An overview.Journal of biosciences · 2003
• Exploring the Complex Role of Coagulation Factor VIII in Chronic Liver Disease.Cellular and molecular gastroenterology and hepatology · 2021

via PubMed

• COMPLETED
  Are There Differences Between Carriers of Haemophilia A and B?Cliniques universitaires Saint-Luc- Université Catholique de Louvain · NCT05217992
• PHASE1COMPLETED
  Study of FVIIa Variant BAY86-6150 (B0189) in Subjects With Moderate or Severe Hemophilia Types A or B With or Without InhibitorsBayer · NCT01921855
• PHASE1NOT_YET_RECRUITING
  Hematopoietic Stem Cell Transplantation Gene Therapy for Treatment of Severe Hemophilia AExpression Therapeutics, LLC · NCT04418414
• PHASE3COMPLETED
  Study Evaluating BDDRFVIII and ReFacto AF in Hemophilia AWyeth is now a wholly owned subsidiary of Pfizer · NCT00038935
• COMPLETED
  Study of Prophylaxis, ACtivity and Effectiveness (SPACE) in Hemophilia Patients Currently Treated With ADVATE or RIXUBISBaxalta now part of Shire · NCT02190149
• PHASE3COMPLETED
  Evaluation of Safety and Efficacy, Including Pharmacokinetics, of NNC 0129-0000-1003 When Administered for Treatment and Prophylaxis of Bleeding in Subjects With Haemophilia ANovo Nordisk A/S · NCT01480180

via ClinicalTrials.gov

Wikidata facts

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protein

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