
Also known as colon cancer, rectal cancer, large intestine cancer, Colorectal cancer, familial, bowel cancer, colon and rectal cancer, rectocolonic cancer
Colorectal cancer, also known as bowel cancer, colon cancer, or rectal cancer, is the development of cancer from the colon or rectum. It is the consequence of uncontrolled growth of colon cells that can invade/spread to other parts of the body. Signs and symptoms may include blood in the stool, a change in bowel movements, weight loss, abdominal pain and fatigue. Most colorectal cancers are due to lifestyle factors and genetic disorders. Risk factors include diet, obesity, smoking, and lack of physical activity. Dietary factors that increase the risk include red meat, processed meat, and alcohol. Another risk factor is inflammatory bowel disease, which includes Crohn's disease and ulcerative colitis. Some of the inherited genetic disorders that can cause colorectal cancer include familial adenomatous polyposis and hereditary non-polyposis colon cancer; however, these represent less than 5% of cases. It typically starts as a benign tumor, often in the form of a polyp, which over time becomes cancerous.
Colorectal cancer is a disease in which cancer develops in the colon or rectum due to uncontrolled growth of cells that can spread to other parts of the body, and it matters because it is commonly caused by preventable lifestyle factors such as diet, obesity, smoking, and lack of physical activity, though genetic factors also play a role. Early signs like blood in the stool, changes in bowel movements, weight loss, abdominal pain, and fatigue can help with detection and treatment.
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大腸直腸癌(英語:Colorectal cancer),又稱為大腸癌、直腸癌、大肠直肠癌、结肠直肠癌、或腸癌,為源自結腸或直腸(為大腸的一部份)的癌症。因為細胞不正常的生長,可能侵犯或轉移至身體其他部。症狀可能包括、排便習慣改變、體重減輕、以及疲倦感。 大部份的大腸直腸癌起因為生活習慣及老化,少部分則因為遺傳疾病。風險因子包括飲食、肥胖、抽煙、運動量不足。增加罹癌風險的飲食包含紅肉或加工肉品、以及酒精。其他風險因子包含發炎性腸道疾病(分為克隆氏症和潰瘍性大腸炎)。某些可能造成大腸直腸癌的遺傳疾病為家族性結直腸瘜肉綜合症和,然而這些遺傳性疾病占大腸直腸癌所有病例中的比例不到5%。大腸直腸癌通常源自良性腫瘤,然而隨時間進展變成惡性腫瘤。 腸癌的診斷可藉由或檢查切片。接著由影像檢查查看是否轉移。進行大腸直腸癌的可有效降低死亡率,目前建議50歲以上至75歲規則接受篩檢。阿斯匹靈及其他非類固醇抗發炎藥物可降低罹癌風險,但由於藥物的副作用,目前並不建議常規使用它們來預防大腸直腸癌的發生。 治療方式包括手術、放射線治療、化學治療、及標靶治療或是合併使用以上療法。侷限在腸壁的大腸直腸癌可能藉由手術治癒,然而當癌症已擴散或轉移時則不然,此時則以改善生活品質及症狀為治療目標。在美國,五年存活率約65%,然而主要取決於病人健康狀況與癌症分期,而分期又關係到是否能藉由手術移除。整體來說,大腸直腸癌為第三常見癌症,約占10%。在2012年,有140萬例新診斷的大腸直腸癌,且造成69.4萬人死亡。大腸直腸癌在已開發國家較為常見,占全世界總案例數的65%。而在女性較男性少見。
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Discovered by embedding cosine similarity (sentence-transformers MiniLM, 384-dim).