Crohn's disease
Also known as regional enteritis, Crohn disease, Crohn's disease of colon (disorder), Crohn's disease of large bowel, Granulomatous Colitis, regional Ileitis, regional colitis, regional enteritis of small intestine with large intestine
type of inflammatory bowel disease
AI overview
Crohn's disease is a type of inflammatory bowel disease that causes inflammation in the digestive tract. It matters because it can cause serious symptoms and complications that affect a person's digestive health and quality of life.
AI-generated from the Wikipedia summary — may contain errors.
Research
76,633 papers- Pathophysiology of Crohn's disease inflammation and recurrence.ReviewBiology direct · 2020Petagna L, Antonelli A, Ganini C et al.DOI: 10.1186/s13062-020-00280-5
- Crohn's disease: an update.Clinical medicine (London, England) · 2023Cockburn E, Kamal S, Chan A et al.DOI: 10.7861/clinmed.2023-0493
- Crohn's disease.ReviewMedicina clinica · 2018Ballester Ferré MP, Boscá-Watts MM, Mínguez Pérez MDOI: 10.1016/j.medcli.2017.10.036
- Pediatric Management of Crohn's Disease.ReviewGastroenterology clinics of North America · 2022Mitchel EB, Rosh JRDOI: 10.1016/j.gtc.2021.12.013
Article
Crohn's disease is a type of inflammatory bowel disease (IBD) that may affect any segment of the gastrointestinal tract. Symptoms often include abdominal pain, diarrhea, fever, abdominal distension, and weight loss. Complications outside of the gastrointestinal tract may include anemia, skin rashes, arthritis, inflammation of the eye, and fatigue. The skin rashes may be due to infections, as well as pyoderma gangrenosum or erythema nodosum. Bowel obstruction may occur as a complication of chronic inflammation, and those with the disease are at much greater risk of colorectal cancer and small bowel cancer.
Although the precise causes of Crohn's disease (CD) are unknown, it is believed to be caused by a combination of environmental, immune, and bacterial factors in genetically susceptible individuals. It results in a chronic inflammatory disorder, in which the body's immune system defends the gastrointestinal tract, possibly targeting microbial antigens. Although Crohn's is an immune-related disease, it does not seem to be an autoimmune disease (the immune system is not triggered by the body itself). The exact underlying immune problem is not clear, though it may be immunodeficiency.