CRYGB

Name

crystallin gamma B

Type

protein-coding

Position

208,142,573–208,146,158 (−)

Aliases

CRYG2, CTRCT39

Ensembl

ENSG00000182187

RefSeq RNA

NM_005210.4, XM_017003402.2, XM_054340639.1

RefSeq protein

NP_005201.2, XP_016858891.1, XP_054196614.1

Crystallins are separated into two classes: taxon-specific, or enzyme, and ubiquitous. The latter class constitutes the major proteins of vertebrate eye lens and maintains the transparency and refractive index of the lens. Since lens central fiber cells lose their nuclei during development, these crystallins are made and then retained throughout life, making them extremely stable proteins. Mammalian lens crystallins are divided into alpha, beta, and gamma families; beta and gamma crystallins are also considered as a superfamily. Alpha and beta families are further divided into acidic and basic groups. Seven protein regions exist in crystallins: four homologous motifs, a connecting peptide, and N- and C-terminal extensions. Gamma-crystallins are a homogeneous group of highly symmetrical, monomeric proteins typically lacking connecting peptides and terminal extensions. They are differentially regulated after early development. Four gamma-crystallin genes (gamma-A through gamma-D) and three pseudogenes (gamma-E, gamma-F, gamma-G) are tandemly organized in a genomic segment as a gene cluster. Whether due to aging or mutations in specific genes, gamma-crystallins have been involved in cataract formation. [provided by RefSeq, Jul 2008].

via MyGene.info

Gene · Ensembl

crystallin gamma B

Symbol

CRYGB

Biotype

Protein coding

Organism

Homo sapiens

Location

2:208,142,573-208,146,163

Strand

Reverse (−)

Assembly

GRCh38

Wikidata facts

Image

PDB 2jdf EBI.png

via Wikidata · CC0