Wee1
Sign in to saveWee1 is a nuclear kinase belonging to the Ser/Thr family of protein kinases in the fission yeast Schizosaccharomyces pombe (S. pombe). Wee1 has a molecular mass of 96 kDa and is a key regulator of cell cycle progression.
~13 min read
Encyclopedic overview
15 sectionsContents
- Introduction
- Discovery / History
- Function
- Homologues
- Regulation
- Role in cancer
- Wee1 as a target in oncology
- Wee1 expression in tumors
- Wee1 inhibitors
- Clinical development
- Mutant phenotype
- See also
- Notes
- References
- External links
Wee1 is a nuclear kinase belonging to the Ser/Thr family of protein kinases in the fission yeast Schizosaccharomyces pombe (S. pombe). Wee1 has a molecular mass of 96 kDa and is a key regulator of cell cycle progression.
It influences cell size by inhibiting the entry into mitosis, through inhibiting Cdk1. Wee1 has homologues in many other organisms, including mammals.
Excerpted from Wikipedia’s “Wee1” article, available under the CC BY-SA 4.0 licence.