E2F family
Also known as E2F, IPR015633, E2F Transcription Factor, E2F Transcription Factors
E2F is a group of genes that encodes a family of transcription factors (TF) in higher eukaryotes. Three of them are activators: E2F1, 2 and E2F3a. Six others act as repressors: E2F3b, E2F4-8. All of them are involved in the cell cycle regulation and synthesis of DNA in mammalian cells. E2Fs as TFs bind to the TTTCCCGC (or slight variations of this sequence) consensus binding site in the target promoter sequence.
Research
6,958 papers- Posttranslational modifications of E2F family members in the physiological state and in cancer: Roles, mechanisms and therapeutic targets.Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie · 2024
- The broken cycle: E2F dysfunction in cancer.Nature reviews. Cancer · 2019
- Cell cycle regulation: p53-p21-RB signaling.Cell death and differentiation · 2022
- The E2F family: a ray of dawn in cardiomyopathy.Molecular and cellular biochemistry · 2025
- E2F family play important roles in tumorigenesis.Yi chuan = Hereditas · 2023
via PubMed
Article
11 sectionsContents
- E2F family
- Genes
- Structure
- Role in the cell cycle
- E2F/pRb complexes
- Activators: E2F1, E2F2, E2F3a
- Inhibitors: E2F3b, E2F4, E2F5, E2F6, E2F7, E2F8
- Transcriptional targets
- See also
- References
- External links
E2F is a group of genes that encodes a family of transcription factors (TF) in higher eukaryotes. Three of them are activators: E2F1, 2 and E2F3a. Six others act as repressors: E2F3b, E2F4-8. All of them are involved in the cell cycle regulation and synthesis of DNA in mammalian cells. E2Fs as TFs bind to the TTTCCCGC (or slight variations of this sequence) consensus binding site in the target promoter sequence.
==E2F family== Schematic diagram of the amino acid sequences of E2F family members (N-terminus to the left, C-terminus to the right) highlighting the relative locations of functional domains within each member: {| class="wikitable" |- ! Family members ! Legend |- | 400px | cyc A - Cyclin A binding domain DNA - DNA-binding domain DP1,2 - domain for dimerization with DP1, 2 TA - transcriptional activation domain PB - pocket protein binding domain |}