Structure via PubChem · Public domain (PubChem)
Cicloesimide
Sign in to saveAlso known as FT 3422-2, naramycin A, NM-MCD 80, NSC 185, 3-((R)-2-((1S,3S,5S)-3,5-dimethyl-2-oxocyclohexyl)-2-hydroxyethyl)glutarimide, naramycin
farmaco
Chemical data
- Formula
- C15H23NO4
- Molecular weight
- 281.35 g/mol
- IUPAC name
- 4-[(2R)-2-[(1S,3S,5S)-3,5-dimethyl-2-oxocyclohexyl]-2-hydroxyethyl]piperidine-2,6-dione
- SMILES
- C[C@H]1C[C@@H](C(=O)[C@@H](C1)[C@@H](CC2CC(=O)NC(=O)C2)O)C
- InChIKey
- YPHMISFOHDHNIV-FSZOTQKASA-N
- XLogP
- 0.5
- Polar surface area
- 83.5 Ų
- H-bond donors
- 2
- H-bond acceptors
- 4
- Formal charge
- 0
via PubChem
Drug data · ChEMBL
- Max clinical phase
- Phase 2
- Molecule type
- Small molecule
via ChEMBL · EBI
Research
29,679 papers- Discovery and Biosynthesis of Glycosylated Cycloheximide from a Millipede-Associated Actinomycete.Journal of natural products · 2023
- Cycloheximide in dermatology.Acta dermato-venereologica · 1997
- Antifungal Efficacy and Safety of Cycloheximide as a Supplement in Optisol-GS.Drug design, development and therapy · 2021
- Cycloheximide: an adrenergic agent.Life sciences · 1982
- [The effect of translation inhibitor cycloheximide on expression of mammalian genes].Biokhimiia (Moscow, Russia) · 1990
via PubMed
Wikidata facts
- Mass
- 281.163
Show 7 more facts
- Commons category
- Cycloheximide
- chemical formula
- C₁₅H₂₃NO₄
- canonical SMILES
- CC1CC(C(=O)C(C1)C(CC2CC(=O)NC(=O)C2)O)C
- isomeric SMILES
- C[C@H]1C[C@@H](C(=O)[C@@H](C1)[C@@H](CC2CC(=O)NC(=O)C2)O)C
- World Health Organisation international non-proprietary name
- cicloheximide
- found in taxon
- Setosphaeria
- has characteristic
- natural product
via Wikidata · CC0
Article · Italiano
La cicloesimide è un composto chimico che inibisce la sintesi proteica in cellule eucariote bloccando l'attacco e l'uscita del tRNA dal ribosoma. Induce apoptosi in vari tipi cellulari. È prodotta dal batterio Streptomyces griseus.
Abstract from DBpedia / Wikipedia · CC BY-SA