cyperquat
Sign in to saveMPP+ (1-methyl-4-phenylpyridinium) or cyperquat is a positively charged organic molecule with the chemical formula C12H12N+. It is a monoaminergic neurotoxin that acts by interfering with oxidative phosphorylation in mitochondria by inhibiting complex I, leading to the depletion of ATP and eventual cell death.
Article
11 sectionsContents
- History
- Synthesis
- Laboratory
- Biological
- Mechanism of toxicity
- Uses
- In scientific research
- As a [[pesticide]]
- Safety
- References
- External links
MPP+ (1-methyl-4-phenylpyridinium) or cyperquat is a positively charged organic molecule with the chemical formula C12H12N+. It is a monoaminergic neurotoxin that acts by interfering with oxidative phosphorylation in mitochondria by inhibiting complex I, leading to the depletion of ATP and eventual cell death.
MPP+ arises in the body as the toxic metabolite of the closely related compound MPTP. MPTP is converted in the brain into MPP+ by the enzyme MAO-B, ultimately causing parkinsonism in primates by killing certain dopamine-producing neurons in the substantia nigra. The ability for MPP+ to induce Parkinson's disease has made it an important compound in Parkinson's research since this property was discovered in 1983.