Structure via PubChem · Public domain (PubChem)
5,7-dihydroxytryptamine
Sign in to save5,7-Dihydroxytryptamine (5,7-DHT) is a monoaminergic neurotoxin used in scientific research to decrease concentrations of serotonin in the brain. The mechanism behind this effect is not well understood, but it is speculated to selectively destroy serotonergic neurons, in a manner similar to the dopaminergic neurotoxicity of 6-hydroxydopamine (6-OHDA). What is known is that this compound is in fact not selective in depleting serotonin content, but also depletes norepinephrine. To selectively deplete serotonin stores, it is commonly administered in conjunction with desmethylimipramine (desiprami
In the Vinony graph
Within Vinony's link graph, 5,7-dihydroxytryptamine is referenced by 585 other articles, and connects out to oxidopamine, tryptamines and serotonin.
It is catalogued under topics including 5-Hydroxytryptamines, Chembox image size set and ECHA InfoCard ID from Wikidata.
Its subject is documented across 7 Wikipedia language editions.
Chemical data
- Formula
- C10H12N2O2
- Molecular weight
- 192.21 g/mol
- IUPAC name
- 3-(2-aminoethyl)-1H-indole-5,7-diol
via PubChem
Drug data · ChEMBL
- Molecule type
- Small molecule
via ChEMBL · EBI
Research
1,780 papers- Does 5, 7-Dihydroxytryptamine injection into nucleus accumbens cause hyperacusis?Neuroscience letters · 2019
- Inhibition of 5,7-dihydroxytryptamine-induced supersensitivity to 5-hydroxytryptophan in mice by treatment with cycloheximide.Brain research · 1978
- 5,7-Dihydroxytryptamine--a selective marker of dopaminergic or serotonergic neurons?Naunyn-Schmiedeberg's archives of pharmacology · 2002
- Effect of 5,7-dihydroxytryptamine on audiogenic seizures in genetically epilepsy-prone rats.Life sciences · 1996
- 5,7-Dihydroxytryptamine lesions of the ascending 5-hydroxytryptamine pathways: habituation, motor activity and agonistic behavior.Pharmacology, biochemistry, and behavior · 1977
via PubMed
Wikidata facts
- Mass
- 192.09
Show 3 more facts
- chemical formula
- C₁₀H₁₂N₂O₂
- canonical SMILES
- C1=C(C=C2C(=CNC2=C1O)CCN)O
- Commons category
- 5,7-Dihydroxytryptamine
via Wikidata · CC0
~1 min read
Encyclopedic overview
2 sectionsContents
- See also
- References
5,7-Dihydroxytryptamine (5,7-DHT) is a monoaminergic neurotoxin used in scientific research to decrease concentrations of serotonin in the brain. The mechanism behind this effect is not well understood, but it is speculated to selectively destroy serotonergic neurons, in a manner similar to the dopaminergic neurotoxicity of 6-hydroxydopamine (6-OHDA). What is known is that this compound is in fact not selective in depleting serotonin content, but also depletes norepinephrine. To selectively deplete serotonin stores, it is commonly administered in conjunction with desmethylimipramine (desipramine), which inhibits the norepinephrine transporter.
== See also == 4,5-Dihydroxytryptamine 5,6-Dihydroxytryptamine 6,7-Dihydroxytryptamine 4-Hydroxy-5-methoxytryptamine DSP-4 6-Hydroxydopamine (6-OHDA) para-Chlorophenylalanine (PCPA)
Excerpted from Wikipedia’s “5,7-dihydroxytryptamine” article, available under the CC BY-SA 4.0 licence.