5,7-dihydroxytryptamine
Sign in to save5,7-Dihydroxytryptamine (5,7-DHT) is a monoaminergic neurotoxin used in scientific research to decrease concentrations of serotonin in the brain. The mechanism behind this effect is not well understood, but it is speculated to selectively destroy serotonergic neurons, in a manner similar to the dopaminergic neurotoxicity of 6-hydroxydopamine (6-OHDA). What is known is that this compound is in fact not selective in depleting serotonin content, but also depletes norepinephrine. To selectively deplete serotonin stores, it is commonly administered in conjunction with desmethylimipramine (desiprami
Chemical data
- Formula
- C10H12N2O2
- Molecular weight
- 192.21 g/mol
- IUPAC name
- 3-(2-aminoethyl)-1H-indole-5,7-diol
via PubChem
Research
1,780 papers- Does 5, 7-Dihydroxytryptamine injection into nucleus accumbens cause hyperacusis?Neuroscience letters · 2019
- Inhibition of 5,7-dihydroxytryptamine-induced supersensitivity to 5-hydroxytryptophan in mice by treatment with cycloheximide.Brain research · 1978
- 5,7-Dihydroxytryptamine--a selective marker of dopaminergic or serotonergic neurons?Naunyn-Schmiedeberg's archives of pharmacology · 2002
- Effect of 5,7-dihydroxytryptamine on audiogenic seizures in genetically epilepsy-prone rats.Life sciences · 1996
- 5,7-Dihydroxytryptamine lesions of the ascending 5-hydroxytryptamine pathways: habituation, motor activity and agonistic behavior.Pharmacology, biochemistry, and behavior · 1977
via PubMed
Article
2 sectionsContents
- See also
- References
5,7-Dihydroxytryptamine (5,7-DHT) is a monoaminergic neurotoxin used in scientific research to decrease concentrations of serotonin in the brain. The mechanism behind this effect is not well understood, but it is speculated to selectively destroy serotonergic neurons, in a manner similar to the dopaminergic neurotoxicity of 6-hydroxydopamine (6-OHDA). What is known is that this compound is in fact not selective in depleting serotonin content, but also depletes norepinephrine. To selectively deplete serotonin stores, it is commonly administered in conjunction with desmethylimipramine (desipramine), which inhibits the norepinephrine transporter.
== See also == 4,5-Dihydroxytryptamine 5,6-Dihydroxytryptamine 6,7-Dihydroxytryptamine 4-Hydroxy-5-methoxytryptamine DSP-4 6-Hydroxydopamine (6-OHDA) para-Chlorophenylalanine (PCPA)