acetochlor
Sign in to saveAlso known as 2-Chloro-N-(ethoxymethyl)-6'-ethyl-o-acetotoluidide, 2-Chloro-N-(ethoxymethyl)-6'-ethylacet-o-toluidide, 2-Chloro-2'-methyl-6-ethyl-N-ethoxymethylacetanilide
Acetochlor is an herbicide developed by Monsanto Company and Zeneca. It is a member of the class of herbicides known as chloroacetanilides. Its mode of action is elongase inhibition, and inhibition of geranylgeranyl pyrophosphate (GGPP) cyclization enzymes, part of the gibberellin pathway. It carries high risks of environmental contamination. ==Manufacture== Acetochlor is manufactured in two steps from 2-ethyl-6-methylaniline. A reaction with chloroacetyl chloride gives an anilide which is treated with chloromethyl ethyl ether and sodium hydroxide to form the herbicide. 550px
Research
571 papers- Current insights into environmental acetochlor toxicity and remediation strategies.Environmental geochemistry and health · 2024
- A comparative review and computational assessment of acetochlor toxicity in fish: A novel endocrine disruptor?Comparative biochemistry and physiology. Toxicology & pharmacology : CBP · 2023
- The herbicide acetochlor causes lipid peroxidation by inhibition of glutathione peroxidase activity.Toxicological sciences : an official journal of the Society of Toxicology · 2024
- The migration of acetochlor from feed to milk.RSC advances · 2020
- GPR120 exacerbates the immune-inflammatory response in chicken liver by mediating acetochlor induced macrophage M1 polarization.Journal of hazardous materials · 2025
via PubMed
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Encyclopedic overview
8 sectionsContents
- Manufacture
- Uses
- Internationally
- Safety
- Ecologic effects
- See also
- References
- External links
Acetochlor is an herbicide developed by Monsanto Company and Zeneca. It is a member of the class of herbicides known as chloroacetanilides. Its mode of action is elongase inhibition, and inhibition of geranylgeranyl pyrophosphate (GGPP) cyclization enzymes, part of the gibberellin pathway. It carries high risks of environmental contamination. ==Manufacture== Acetochlor is manufactured in two steps from 2-ethyl-6-methylaniline. A reaction with chloroacetyl chloride gives an anilide which is treated with chloromethyl ethyl ether and sodium hydroxide to form the herbicide. 550px
==Uses== In the United States, acetochlor was registered by the EPA as a direct substitute for many herbicides of known concern. The EPA imposed several restrictions and conditions on the use of acetochlor.
Excerpted from Wikipedia’s “acetochlor” article, available under the CC BY-SA 4.0 licence.