Structure via PubChem · Public domain (PubChem)
دسفلوران
Sign in to saveAlso known as I-653, Suprane®, 1,1,1,2-tetrafluoro-2-(difluoromethoxy)ethane, Suprane, (+-)-2-difluoromethyl 1,2,2,2-tetrafluoroethyl ether, difluoromethyl 1,2,2,2-tetrafluoroethyl ether, Desflurano, 1,1,1,2-Tetrafluoro-2-(difluoromethoxy)ethane
Desflurane (1,2,2,2-tetrafluoroethyl difluoromethyl ether), under the brand name Suprane, is a highly fluorinated methyl ethyl ether used for induction and maintenance of general anesthesia. Desflurane was developed in the 1980s and approved by the FDA in 1992 as a faster acting and clearing inhalant anesthetic compared to previously used inhalant anesthetics. Like halothane, enflurane, and isoflurane, it is a racemic mixture of (R) and (S) optical isomers (enantiomers). It has the most rapid onset and offset of the volatile anesthetic drugs used for general anesthesia due to its low solubilit
Chemical data
- Formula
- C3H2F6O
- Molecular weight
- 168.04 g/mol
- IUPAC name
- 2-(difluoromethoxy)-1,1,1,2-tetrafluoroethane
- SMILES
- C(C(F)(F)F)(OC(F)F)F
- InChIKey
- DPYMFVXJLLWWEU-UHFFFAOYSA-N
- XLogP
- 2.6
- Polar surface area
- 9.2 Ų
- H-bond donors
- 0
- H-bond acceptors
- 7
- Formal charge
- 0
via PubChem
Drug data · ChEMBL
- Max clinical phase
- Approved
- Molecule type
- Small molecule
- First approval
- 1992
- Admin. routes
- topical
- Indications
- post-operative sign or symptom, kidney failure
via ChEMBL · EBI
Research
2,976 papers- Desflurane decommissioning: more than meets the eye.Anaesthesia · 2024
- Myocardial Protection by Desflurane: From Basic Mechanisms to Clinical Applications.Journal of cardiovascular pharmacology · 2023
- Desflurane clinical pharmacokinetics and pharmacodynamics.Clinical pharmacokinetics · 1994
- Desflurane versus propofol for general anesthesia maintenance in obese patients: A pilot meta-analysis.Journal of clinical anesthesia · 2021
- Desflurane Should Not Des-appear.Anesthesia and analgesia · 2021
via PubMed
Wikidata facts
- Subclass of
- chemical compound
- Mass
- 168.000984
- Has use
- medication
Show 6 more facts
- chemical formula
- C₃H₂F₆O
- medical condition treated
- pain
- canonical SMILES
- C(C(F)(F)F)(OC(F)F)F
- Commons category
- Desflurane
- subject has role
- inhalational anaesthetic
- global warming potential
- 2143
via Wikidata · CC0