Structure via PubChem · Public domain (PubChem)
didanosine
Sign in to saveAlso known as dideoxyinosine, Videx EC®, 9-((2R,5S)-5-(hydroxymethyl)-tetrahydrofuran-2-yl)-1H-purin-6(9H)-one, 2,3-dideoxyinosine, DDI, ddIno, 9-[(2R,5S)-5-(hydroxymethyl)tetrahydrofuran-2-yl]-1,9-dihydro-6H-purin-6-one, 2′,3′-dideoxyinosine
Didanosine, sold under the brand name Videx among others, is a medication used to treat HIV/AIDS. It is used in combination with other medications as part of highly active antiretroviral therapy (HAART). It is of the reverse-transcriptase inhibitor class.
Key facts
- Drug.NIAID_ChemDB
- 000004
- Drug.Watchedfields
- changed
- Drug.verifiedrevid
- 458775891
- Drug.image
- Didanosin.svg
- Drug.image_class
- skin-invert-image
- Drug.width
- 200
- Drug.image2
- Didanosine ball-and-stick model.png
- Drug.image_class2
- bg-transparent
- Drug.tradename
- Videx, Videx EC
- Drug.MedlinePlus
- a691006
- Drug.pregnancy_AU
- B2
- Drug.routes_of_administration
- By mouth
- Drug.ATC_prefix
- J05
- Drug.ATC_suffix
- AF02
- Drug.legal_UK
- POM
- Drug.legal_US
- Rx-only
- Drug.bioavailability
- 30 to 54%
- Drug.protein_bound
- Less than 5%
via Wikipedia infobox
Chemical data
- Formula
- C10H12N4O3
- Molecular weight
- 236.23 g/mol
- IUPAC name
- 9-[(2R,5S)-5-(hydroxymethyl)oxolan-2-yl]-3H-purin-6-one
- SMILES
- C1C[C@@H](O[C@@H]1CO)N2C=NC3=C2NC=NC3=O
- InChIKey
- BXZVVICBKDXVGW-NKWVEPMBSA-N
- XLogP
- -1.2
- Polar surface area
- 88.7 Ų
- H-bond donors
- 2
- H-bond acceptors
- 4
- Formal charge
- 0
via PubChem
Drug data · ChEMBL
- Max clinical phase
- Approved
- Molecule type
- Small molecule
- First approval
- 1991
- Admin. routes
- oral
- Indications
- HIV infection, lymphoma, AIDS, AIDS related complex
via ChEMBL · EBI
Research
2,882 papers- Didanosine.The Annals of pharmacotherapy · 1992
- [Didanosine].Enfermedades infecciosas y microbiologia clinica · 1995
- Update on didanosine.Journal of the International Association of Physicians in AIDS Care (Chicago, Ill. : 2002) · 2002
- Didanosine-induced Retinopathy: New Insights with Long-term Follow-up.Ocular immunology and inflammation · 2022
- Zalcitabine and didanosine.Lancet (London, England) · 1993
via PubMed
Wikidata facts
- Subclass of
- nucleoside analogue
- Mass
- 236.091
- Has use
- medication
Show 10 more facts
- chemical formula
- C₁₀H₁₂N₄O₃
- medical condition treated
- HIV infection
- canonical SMILES
- C1CC(OC1CO)N2C=NC3=C2NC=NC3=O
- isomeric SMILES
- C1C[C@@H](O[C@@H]1CO)N2C=NC3=C2NC=NC3=O
- World Health Organisation international non-proprietary name
- didanosine
- defined daily dose
- 0.4
- subject has role
- antiviral drug
- Commons category
- Didanosine
- legal status (medicine)
- boxed warning
- significant drug interaction
- ribavirin
Sources (6)
via Wikidata · CC0
~5 min read
Encyclopedic overview
8 sectionsContents
- Adverse effects
- Drug interactions
- Resistance
- Mechanism of action
- Pharmacokinetics
- History
- References
- Further reading
Didanosine, sold under the brand name Videx among others, is a medication used to treat HIV/AIDS. It is used in combination with other medications as part of highly active antiretroviral therapy (HAART). It is of the reverse-transcriptase inhibitor class.
Didanosine was first described in 1975 and approved for use in the United States in 1991.
Excerpted from Wikipedia’s “didanosine” article, available under the CC BY-SA 4.0 licence.