dideoxynucleotide
Sign in to savethumb|Molecular structure of 2',3'-dideoxyadenosine triphosphate (ddATP)
Research
1,242 papers- LINE1 Derepression in Aged Wild-Type and SIRT6-Deficient Mice Drives Inflammation.Cell metabolism · 2019
- The novel HLA-A*68:302 allele, identified by Sanger dideoxynucleotide sequencing in a Chinese individual.HLA · 2023
- Next-generation sequencing platforms.Annual review of analytical chemistry (Palo Alto, Calif.) · 2013
- Structure-based design of Taq DNA polymerases with improved properties of dideoxynucleotide incorporation.Proceedings of the National Academy of Sciences of the United States of America · 1999
- UV-induced bond modifications in thymine and thymine dideoxynucleotide: structural elucidation of isomers by differential mobility mass spectrometry.Analytical chemistry · 2010
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5 sectionsContents
- Role in the Sanger method
- DNA Sequencing
- Production
- References
- External links
thumb|Molecular structure of 2',3'-dideoxyadenosine triphosphate (ddATP)
Dideoxynucleotides are chain-elongating inhibitors of DNA polymerase, used in the Sanger method for DNA sequencing. They are also known as 2',3' because both the 2' and 3' positions on the ribose lack hydroxyl groups, and are abbreviated as ddNTPs (ddGTP, ddATP, ddTTP and ddCTP).
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