Structure via PubChem · Public domain (PubChem)
doravirine
Sign in to saveAlso known as MK-1439, Pifeltro
Doravirine, sold under the brand name Pifeltro, is a non-nucleoside reverse transcriptase inhibitor medication developed by Merck & Co. for use in the treatment of HIV/AIDS.
Chemical data
- Formula
- C17H11ClF3N5O3
- Molecular weight
- 425.7 g/mol
- IUPAC name
- 3-chloro-5-[[1-[(4-methyl-5-oxo-1H-1,2,4-triazol-3-yl)methyl]-2-oxo-4-(trifluoromethyl)-3-pyridinyl]oxy]benzonitrile
- SMILES
- CN1C(=NNC1=O)CN2C=CC(=C(C2=O)OC3=CC(=CC(=C3)C#N)Cl)C(F)(F)F
- InChIKey
- ZIAOVIPSKUPPQW-UHFFFAOYSA-N
- XLogP
- 2.1
- Polar surface area
- 98 Ų
- H-bond donors
- 1
- H-bond acceptors
- 8
- Formal charge
- 0
via PubChem
Drug data · ChEMBL
- Max clinical phase
- Approved
- Molecule type
- Small molecule
- First approval
- 2018
- Admin. routes
- oral
- Indications
- HIV-1 infection, HIV infection, viral disease, kidney disease
via ChEMBL · EBI
Wikidata facts
- Subclass of
- chemical compound
- Mass
- 425.05
- Has use
- medication
Show 3 more facts
- canonical SMILES
- CN1C(=NNC1=O)CN2C=CC(=C(C2=O)OC3=CC(=CC(=C3)C#N)Cl)C(F)(F)F
- chemical formula
- C₁₇H₁₁ClF₃N₅O₃
- Commons category
- Doravirine
via Wikidata · CC0
~3 min read
Encyclopedic overview
2 sectionsContents
- Synthesis
- References
{{Drugbox | image = Doravirine.svg | image_class = skin-invert-image | alt = | caption =
| tradename = Pifeltro | Drugs.com = | MedlinePlus = a618048 | DailyMedID = Doravirine | pregnancy_AU = | pregnancy_category = | routes_of_administration = By mouth | ATC_prefix = J05 | ATC_suffix = AG06 | ATC_supplemental =
Excerpted from Wikipedia’s “doravirine” article, available under the CC BY-SA 4.0 licence.