Structure via PubChem · Public domain (PubChem)
دوکساپرام
Sign in to saveAlso known as AHR-619, Dopram®, (+-)-doxapram, 1-ethyl-4-(2-morpholinoethyl)-3,3-diphenyl-2-pyrrolidinone, (+-)-Doxapram, 1-Ethyl-4-(2-morpholinoethyl)-3,3-diphenyl-2-pyrrolidinone, Doxapramum, Doxapram
Doxapram is a respiratory stimulant, or analeptic. Administered intravenously, doxapram stimulates an increase in tidal volume, and respiratory rate.
Chemical data
- Formula
- C24H30N2O2
- Molecular weight
- 378.5 g/mol
- IUPAC name
- 1-ethyl-4-(2-morpholin-4-ylethyl)-3,3-diphenylpyrrolidin-2-one
- SMILES
- CCN1CC(C(C1=O)(C2=CC=CC=C2)C3=CC=CC=C3)CCN4CCOCC4
- InChIKey
- XFDJYSQDBULQSI-UHFFFAOYSA-N
- XLogP
- 3.3
- Polar surface area
- 32.8 Ų
- H-bond donors
- 0
- H-bond acceptors
- 3
- Formal charge
- 0
via PubChem
Drug data · ChEMBL
- Max clinical phase
- Approved
- Molecule type
- Small molecule
- First approval
- 1965
- Admin. routes
- parenteral
- Indications
- panic disorder, respiratory system disease
via ChEMBL · EBI
Research
698 papers- Doxapram for the prevention and treatment of apnea in preterm infants.The Cochrane database of systematic reviews · 2023
- Doxapram Treatment for Apnea of Prematurity: A Systematic Review.Neonatology · 2017
- Not the classical serendipity: does doxapram treat atrial fibrillation?Cardiovascular research · 2022
- Doxapram treatment for apnea in preterm infants.The Cochrane database of systematic reviews · 2004
- Doxapram.Lancet (London, England) · 1973
via PubMed
Wikidata facts
- Subclass of
- chemical compound
- Mass
- 378.231
- Has use
- medication
Show 6 more facts
- chemical formula
- C₂₄H₃₀N₂O₂
- medical condition treated
- substance use disorder
- canonical SMILES
- CCN1CC(C(C1=O)(C2=CC=CC=C2)C3=CC=CC=C3)CCN4CCOCC4
- World Health Organisation international non-proprietary name
- doxapram
- defined daily dose
- 0.4
- Commons category
- Doxapram
via Wikidata · CC0