amiphenazole
Sign in to saveAlso known as 5-phenyl-1,3-thiazole-2,4-diamine
Amiphenazole (Daptazile) is a respiratory stimulant traditionally used as an antidote for barbiturate or opiate overdose, usually in combination with bemegride, as well as poisoning from other sedative drugs and treatment of respiratory failure from other causes. It was considered particularly useful as it could counteract the sedation and respiratory depression produced by morphine but with less effect on analgesia. It is still rarely used in medicine in some countries, although it has largely been replaced by more effective respiratory stimulants such as doxapram and specific opioid antagoni
Research
49 papers- AMIPHENAZOLE and morphine.British medical journal · 1956
- AMIPHENAZOLE AND BRONCHITIS.British medical journal · 1963
- Bemegride and Amiphenazole.Canadian Medical Association journal · 1957
- RASHES WITH AMIPHENAZOLE.British medical journal · 1964
- Amiphenazole in a case of drug addiction.Lancet (London, England) · 1957
via PubMed
Wikidata facts
- Subclass of
- chemical compound
- Mass
- 191.052
Show 3 more facts
- canonical SMILES
- C1=CC=C(C=C1)C2=C(N=C(S2)N)N
- chemical formula
- C₉H₉N₃S
- Commons category
- Amiphenazole
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Encyclopedic overview
1 sectionsContents
- References
Amiphenazole (Daptazile) is a respiratory stimulant traditionally used as an antidote for barbiturate or opiate overdose, usually in combination with bemegride, as well as poisoning from other sedative drugs and treatment of respiratory failure from other causes. It was considered particularly useful as it could counteract the sedation and respiratory depression produced by morphine but with less effect on analgesia. It is still rarely used in medicine in some countries, although it has largely been replaced by more effective respiratory stimulants such as doxapram and specific opioid antagonists such as naloxone.
== References ==
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