Structure via PubChem · Public domain (PubChem)
drotaverine
Sign in to saveAlso known as Drotaverin, Drotin
Drotaverine (INN, also known as drotaverin) is an antispasmodic drug, used to enhance cervical dilation during childbirth and to relieve smooth muscle spasms in the gastrointestinal tract, urinary system, and gall bladder.
Chemical data
- Formula
- C24H31NO4
- Molecular weight
- 397.5 g/mol
- IUPAC name
- (1Z)-1-[(3,4-diethoxyphenyl)methylidene]-6,7-diethoxy-3,4-dihydro-2H-isoquinoline
- SMILES
- CCOC1=C(C=C(C=C1)/C=C\2/C3=CC(=C(C=C3CCN2)OCC)OCC)OCC
- InChIKey
- OMFNSKIUKYOYRG-MOSHPQCFSA-N
- XLogP
- 5.4
- Polar surface area
- 49 Ų
- H-bond donors
- 1
- H-bond acceptors
- 5
- Formal charge
- 0
via PubChem
Drug data · ChEMBL
- Max clinical phase
- Phase 3
- Molecule type
- Small molecule
- Indications
- gastrointestinal disease, bile duct disorder
via ChEMBL · EBI
Research
209 papers- Drotaverine.2006
- Drotaverine-induced priapism.Indian journal of urology : IJU : journal of the Urological Society of India · 2021
- Drotaverine to shorten the duration of labour in primigravidas: a randomised, double-blind, placebo-controlled trial.African health sciences · 2022
- Drotaverine for Recurrent Abdominal Pain in Children.Indian pediatrics · 2015
- Drotaverine - a Concealed Cytostatic!Archiv der Pharmazie · 2017
via PubMed
Wikidata facts
- Subclass of
- chemical compound
- Mass
- 397.225308
- Has use
- medication
Show 6 more facts
- chemical formula
- C₂₄H₃₁NO₄
- World Health Organisation international non-proprietary name
- drotaverine
- subject has role
- parasympatholytic
- canonical SMILES
- CCOC1=C(C=C(C=C1)C=C2C3=CC(=C(C=C3CCN2)OCC)OCC)OCC
- isomeric SMILES
- CCOC1=C(C=C(C=C1)/C=C\2/C3=CC(=C(C=C3CCN2)OCC)OCC)OCC
- Commons category
- Drotaverine
Sources (1)
via Wikidata · CC0
~3 min read
Encyclopedic overview
5 sectionsContents
- Pharmacodynamics
- Side effects
- Counterfeits
- Risks
- References
Drotaverine (INN, also known as drotaverin) is an antispasmodic drug, used to enhance cervical dilation during childbirth and to relieve smooth muscle spasms in the gastrointestinal tract, urinary system, and gall bladder.
It is structurally related to papaverine, is a phosphodiesterase inhibitor and has no anticholinergic effects.
Excerpted from Wikipedia’s “drotaverine” article, available under the CC BY-SA 4.0 licence.