DUSP5

Also known as DUSP, HVH3, dual specificity phosphatase 5

gene da espécie Homo sapiens

In the Vinony graph

Within Vinony's link graph, DUSP5 is referenced by 83 other articles, and connects out to PubMed, human chromosome 10 and Ensembl genome database project.

Vinony files it under EC 3.1.3 and Genes on human chromosome 10.

Its subject is documented across 4 Wikipedia language editions.

Gene data

DUSP5

Name: dual specificity phosphatase 5
Type: protein-coding
Position: 110,497,907–110,511,544 (+)
Aliases: DUSP, HVH3
Ensembl: ENSG00000138166
RefSeq RNA: NM_004419.4
RefSeq protein: NP_004410.3

The protein encoded by this gene is a member of the dual specificity protein phosphatase subfamily. These phosphatases inactivate their target kinases by dephosphorylating both the phosphoserine/threonine and phosphotyrosine residues. They negatively regulate members of the mitogen-activated protein (MAP) kinase superfamily (MAPK/ERK, SAPK/JNK, p38), which are associated with cellular proliferation and differentiation. Different members of the family of dual specificity phosphatases show distinct substrate specificities for various MAP kinases, different tissue distribution and subcellular localization, and different modes of inducibility of their expression by extracellular stimuli. This gene product inactivates ERK1, is expressed in a variety of tissues with the highest levels in pancreas and brain, and is localized in the nucleus. [provided by RefSeq, Jul 2008].